TY - JOUR
T1 - Development and optimisation of grid inserts for a preclinical radiotherapy system and corresponding Monte Carlo beam simulations
AU - Fisk, Marcus
AU - Rowshanfarzad, Pejman
AU - Pfefferlé, David
AU - Viana, Matthew Fernandez de
AU - Cabrera, Julian
AU - Ebert, Martin Andrew
PY - 2024/3/7
Y1 - 2024/3/7
N2 - Objective: To Develop a physical grid collimator compatible with the X-RAD preclinical radiotherapy system and create a corresponding Monte Carlo (MC) model.
Approach: This work presents a methodology for the fabrication of a grid collimator designed for utilisation on the X-RAD preclinical radiotherapy system. Additionally, a MC simulation of the grid is developed, which is compatible with the X-RAD treatment planning system. The grid was manufactured by casting a low melting point alloy, cerrobend, into a silicone mould. The silicone was moulded around a 3D-printed replica of the grid, enabling the production of diverging holes with precise radii and spacing. A MC simulation was conducted on an equivalent 3D grid model and validated using 11 layers of GAFChromic EBT-3 film interspersed in a 3D-printed water-equivalent phantom. A 3D dose distribution was constructed from the film layers, enabling a direct comparison with the MC Simulation.
Main results: The film and the MC dose distribution demonstrated a gamma passing rate of 99% for a 1%, 0.5mm criteria with a 10% threshold applied. The peak-to-valley dose ratio (PVDR) and output factor at the surface were determined to be 20.4 and 0.79, respectively.
Significance: The pairing of the grid collimator with a MC simulation can significantly enhance the practicality of grid therapy on the X-RAD. This combination enables further exploration of the biological implications of grid therapy, supported by a knowledge of the complex dose distributions. Moreover, this methodology can be adapted for use in other systems and scenarios.
AB - Objective: To Develop a physical grid collimator compatible with the X-RAD preclinical radiotherapy system and create a corresponding Monte Carlo (MC) model.
Approach: This work presents a methodology for the fabrication of a grid collimator designed for utilisation on the X-RAD preclinical radiotherapy system. Additionally, a MC simulation of the grid is developed, which is compatible with the X-RAD treatment planning system. The grid was manufactured by casting a low melting point alloy, cerrobend, into a silicone mould. The silicone was moulded around a 3D-printed replica of the grid, enabling the production of diverging holes with precise radii and spacing. A MC simulation was conducted on an equivalent 3D grid model and validated using 11 layers of GAFChromic EBT-3 film interspersed in a 3D-printed water-equivalent phantom. A 3D dose distribution was constructed from the film layers, enabling a direct comparison with the MC Simulation.
Main results: The film and the MC dose distribution demonstrated a gamma passing rate of 99% for a 1%, 0.5mm criteria with a 10% threshold applied. The peak-to-valley dose ratio (PVDR) and output factor at the surface were determined to be 20.4 and 0.79, respectively.
Significance: The pairing of the grid collimator with a MC simulation can significantly enhance the practicality of grid therapy on the X-RAD. This combination enables further exploration of the biological implications of grid therapy, supported by a knowledge of the complex dose distributions. Moreover, this methodology can be adapted for use in other systems and scenarios.
U2 - 10.1088/1361-6560/ad21a1
DO - 10.1088/1361-6560/ad21a1
M3 - Article
C2 - 38262060
SN - 1361-6560
VL - 69
JO - Physics in Medicine & Biology
JF - Physics in Medicine & Biology
IS - 5
M1 - 055010
ER -