Development and evaluation of taste masked paediatric medicinal formulations

Okhee Yoo

doi:10.26182/p222-f672

Development and evaluation of taste masked paediatric medicinal formulations

Okhee Yoo

Research output: Thesis › Doctoral Thesis

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Abstract

The aim of this thesis was to develop and evaluate novel peroral taste-masked paediatric medicinal products. The thesis firstly reports on the clinical evaluation of a novel tramadol chocolate-based delivery system (CDS) for taste acceptance and comparative population pharmacokinetics against a compounded tramadol hydrochloride oral liquid as comparator. A validated high performance liquid chromatography assay was developed to quantify tramadol and O-desmethyltramadol in human plasma in the presence of seven potentially interfering drugs. The second section of the thesis reports on the development via Design of Experiments of a novel taste masked formulation of the bitter antibiotic flucloxacillin.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Lim, Lee Yong, Supervisor Regli-von Ungern-Sternberg, Britta, Supervisor Salman, Sam, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	16 Mar 2022
DOIs	https://doi.org/10.26182/p222-f672
Publication status	Unpublished - 2022

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Embargoed from 24/03/2022 to 03/03/2024. Made publicly available on 03/03/2024.

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10.26182/p222-f672

THESIS - DOCTOR OF PHILOSOPHY - YOO Okhee - 2022
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Cite this

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title = "Development and evaluation of taste masked paediatric medicinal formulations",

abstract = "The aim of this thesis was to develop and evaluate novel peroral taste-masked paediatric medicinal products. The thesis firstly reports on the clinical evaluation of a novel tramadol chocolate-based delivery system (CDS) for taste acceptance and comparative population pharmacokinetics against a compounded tramadol hydrochloride oral liquid as comparator. A validated high performance liquid chromatography assay was developed to quantify tramadol and O-desmethyltramadol in human plasma in the presence of seven potentially interfering drugs. The second section of the thesis reports on the development via Design of Experiments of a novel taste masked formulation of the bitter antibiotic flucloxacillin.",

keywords = "Tramadol, Population pharmacokinetic, Paediatric medicine, Taste masking, Relative bioavailability, Design of experiments, Mixture design, Flucloxacillin",

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AB - The aim of this thesis was to develop and evaluate novel peroral taste-masked paediatric medicinal products. The thesis firstly reports on the clinical evaluation of a novel tramadol chocolate-based delivery system (CDS) for taste acceptance and comparative population pharmacokinetics against a compounded tramadol hydrochloride oral liquid as comparator. A validated high performance liquid chromatography assay was developed to quantify tramadol and O-desmethyltramadol in human plasma in the presence of seven potentially interfering drugs. The second section of the thesis reports on the development via Design of Experiments of a novel taste masked formulation of the bitter antibiotic flucloxacillin.

KW - Tramadol

KW - Population pharmacokinetic

KW - Paediatric medicine

KW - Taste masking

KW - Relative bioavailability

KW - Design of experiments

KW - Mixture design

KW - Flucloxacillin

U2 - 10.26182/p222-f672

DO - 10.26182/p222-f672

M3 - Doctoral Thesis

ER -

Development and evaluation of taste masked paediatric medicinal formulations

Abstract

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