Development and characterisation of an optimised basic fibroblast growth factor (FGF-2) formulation for the repair of chronic tympanic membrane perforations

Research output: ThesisDoctoral Thesis

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Abstract

Chronic tympanic membrane perforations are conventionally treated with expensive surgical procedures. The application of basic fibroblast growth factor (FGF-2) within a supportive scaffold promises a minimally invasive alternative, however, the instability of FGF-2 limited its clinical use. This study demonstrated successful methods for FGF-2 stabilisation that potentiated its cellular proliferative, migratory and wound healing effects in vitro compared with non-stabilised FGF-2. Additionally, alginate-based scaffold products incorporating stabilised FGF-2 demonstrated more favourable cellular interactions and sustained cellular proliferation in vitro than controls, providing a promising basis for their further development into medicinal products for the repair of chronic tympanic membrane perforations.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Lim, Lee Yong, Supervisor
  • Rajan, Gunesh, Supervisor
  • Locher, Connie, Supervisor
Thesis sponsors
Award date11 Oct 2020
DOIs
Publication statusUnpublished - 2020

Embargo information

  • Embargoed from 05/11/2020 to 22/08/2022. Made publicly available on 22/08/2022.

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