Chronic tympanic membrane perforations are conventionally treated with expensive surgical procedures. The application of basic fibroblast growth factor (FGF-2) within a supportive scaffold promises a minimally invasive alternative, however, the instability of FGF-2 limited its clinical use. This study demonstrated successful methods for FGF-2 stabilisation that potentiated its cellular proliferative, migratory and wound healing effects in vitro compared with non-stabilised FGF-2. Additionally, alginate-based scaffold products incorporating stabilised FGF-2 demonstrated more favourable cellular interactions and sustained cellular proliferation in vitro than controls, providing a promising basis for their further development into medicinal products for the repair of chronic tympanic membrane perforations.
|Doctor of Philosophy
|11 Oct 2020
|Unpublished - 2020
- Embargoed from 05/11/2020 to 22/08/2022. Made publicly available on 22/08/2022.