Developing NHC-Iridium Catalysts for the Highly Efficient Enantioselective Intramolecular Hydroamination Reaction

Pengchao Gao, Gellert Sipos, Daven Foster, Reto Dorta

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Chiral, cationic NHC-iridium complexes are introduced as catalysts for the intramolecular hydroamination reaction of unactivated aminoalkenes. The catalysts show high activity in the construction of pyrrolidines, which are accessed with excellent optical purity. Enantiomerically enriched piperidines and indolines are also produced, and various functional groups are tolerated with this LTM system. A reaction mechanism is proposed, and a major deactivation pathway of these catalysts is presented and discussed.

Original languageEnglish
Pages (from-to)6060-6064
Number of pages5
JournalACS Catalysis
Issue number9
Publication statusPublished - Sep 2017

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