Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Michael D. Wallace; Nidda F. Waraich; Aleksandra W. Debowski; Maxime G. Corral; Anthony Maxwell; Joshua S. Mylne; Keith A. Stubbs

doi:10.1039/c7cc09518j

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Michael D. Wallace, Nidda F. Waraich, Aleksandra W. Debowski, Maxime G. Corral, Anthony Maxwell, Joshua S. Mylne, Keith A. Stubbs

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

Original language	English
Pages (from-to)	1869-1872
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	15
DOIs	https://doi.org/10.1039/c7cc09518j
Publication status	Published - 21 Feb 2018

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10.1039/c7cc09518j

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abstract = "Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.",

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AU - Corral, Maxime G.

AU - Maxwell, Anthony

AU - Mylne, Joshua S.

AU - Stubbs, Keith A.

PY - 2018/2/21

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Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Abstract

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Using Genetic Tools to Study Helicobacter Pylori & Persistence

Genetic evolution of plant proteins with biomedical applications

The Development of Tools to Study Carbohydrate-Processing Enzymes Implicated in Human Disease

The Synthesis and Application of Chemical Tools to Study Specific Plant and Bacterial Enzymes

Cite this

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Abstract

Access to Document

Other files and links

Fingerprint

Projects

Using Genetic Tools to Study Helicobacter Pylori & Persistence

Genetic evolution of plant proteins with biomedical applications

The Development of Tools to Study Carbohydrate-Processing Enzymes Implicated in Human Disease

Research output

The Synthesis and Application of Chemical Tools to Study Specific Plant and Bacterial Enzymes

Cite this