Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Michael D. Wallace; Nidda F. Waraich; Aleksandra W. Debowski; Maxime G. Corral; Anthony Maxwell; Joshua S. Mylne; Keith A. Stubbs

doi:10.1039/c7cc09518j

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Michael D. Wallace, Nidda F. Waraich, Aleksandra W. Debowski, Maxime G. Corral, Anthony Maxwell, Joshua S. Mylne, Keith A. Stubbs

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

Original language	English
Pages (from-to)	1869-1872
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	15
DOIs	https://doi.org/10.1039/c7cc09518j
Publication status	Published - 21 Feb 2018

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10.1039/c7cc09518j

http://www.scopus.com/inward/record.url?scp=85042198496&partnerID=8YFLogxK

3 Finished

Using Genetic Tools to Study Helicobacter Pylori & Persistence
Debowski, A.
National Health & Medical Research Council NHMRC
1/01/14 → 28/02/18
Project: Research
Genetic evolution of plant proteins with biomedical applications
Mylne, J.
Australian Research Council
1/01/12 → 30/06/17
Project: Research
The Development of Tools to Study Carbohydrate-Processing Enzymes Implicated in Human Disease
Stubbs, K.
Australian Research Council
1/01/10 → 30/06/15
Project: Research

Cite this

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title = "Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action",

abstract = "Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.",

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AU - Wallace, Michael D.

AU - Waraich, Nidda F.

AU - Debowski, Aleksandra W.

AU - Corral, Maxime G.

AU - Maxwell, Anthony

AU - Mylne, Joshua S.

AU - Stubbs, Keith A.

PY - 2018/2/21

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AB - Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

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Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Abstract

Access to Document

Using Genetic Tools to Study Helicobacter Pylori & Persistence

Genetic evolution of plant proteins with biomedical applications

The Development of Tools to Study Carbohydrate-Processing Enzymes Implicated in Human Disease

Cite this