Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Michael D. Wallace, Nidda F. Waraich, Aleksandra W. Debowski, Maxime G. Corral, Anthony Maxwell, Joshua S. Mylne, Keith A. Stubbs

Research output: Contribution to journalArticle

  • 1 Citations

Abstract

Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

LanguageEnglish
Pages1869-1872
Number of pages4
JournalChemical Communications
Volume54
Issue number15
DOIs
StatePublished - 21 Feb 2018

Cite this

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abstract = "Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.",
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Developing ciprofloxacin analogues against plant DNA gyrase : a novel herbicide mode of action. / Wallace, Michael D.; Waraich, Nidda F.; Debowski, Aleksandra W.; Corral, Maxime G.; Maxwell, Anthony; Mylne, Joshua S.; Stubbs, Keith A.

In: Chemical Communications, Vol. 54, No. 15, 21.02.2018, p. 1869-1872.

Research output: Contribution to journalArticle

TY - JOUR

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T2 - Chemical Communications, 2000

AU - Wallace,Michael D.

AU - Waraich,Nidda F.

AU - Debowski,Aleksandra W.

AU - Corral,Maxime G.

AU - Maxwell,Anthony

AU - Mylne,Joshua S.

AU - Stubbs,Keith A.

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AB - Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

KW - ARABIDOPSIS-THALIANA

KW - EVOLUTION

U2 - 10.1039/c7cc09518j

DO - 10.1039/c7cc09518j

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SP - 1869

EP - 1872

JO - Chemical Communications, 2000

JF - Chemical Communications, 2000

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