Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Michael D. Wallace; Nidda F. Waraich; Aleksandra W. Debowski; Maxime G. Corral; Anthony Maxwell; Joshua S. Mylne; Keith A. Stubbs

doi:10.1039/c7cc09518j

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Michael D. Wallace, Nidda F. Waraich, Aleksandra W. Debowski, Maxime G. Corral, Anthony Maxwell, Joshua S. Mylne, Keith A. Stubbs

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

Original language	English
Pages (from-to)	1869-1872
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	15
DOIs	https://doi.org/10.1039/c7cc09518j
Publication status	Published - 21 Feb 2018

Cite this

Wallace, M. D., Waraich, N. F., Debowski, A. W., Corral, M. G., Maxwell, A., Mylne, J. S., & Stubbs, K. A. (2018). Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action. Chemical Communications, 54(15), 1869-1872. https://doi.org/10.1039/c7cc09518j

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abstract = "Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.",

keywords = "ARABIDOPSIS-THALIANA, EVOLUTION",

author = "Wallace, {Michael D.} and Waraich, {Nidda F.} and Debowski, {Aleksandra W.} and Corral, {Maxime G.} and Anthony Maxwell and Mylne, {Joshua S.} and Stubbs, {Keith A.}",

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AU - Wallace, Michael D.

AU - Waraich, Nidda F.

AU - Debowski, Aleksandra W.

AU - Corral, Maxime G.

AU - Maxwell, Anthony

AU - Mylne, Joshua S.

AU - Stubbs, Keith A.

PY - 2018/2/21

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N2 - Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

AB - Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

KW - ARABIDOPSIS-THALIANA

KW - EVOLUTION

U2 - 10.1039/c7cc09518j

DO - 10.1039/c7cc09518j

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10.1039/c7cc09518j

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Abstract

Cite this

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