Determining the pneumococcal conjugate vaccine coverage required for indirect protection against vaccine-type pneumococcal carriage in low and middle-income countries: A protocol for a prospective observational study

Jocelyn Chan, Cattram D. Nguyen, Jana Y.R. Lai, Eileen M. Dunne, Ross Andrews, Christopher C. Blyth, Siddhartha Datta, Kim Fox, Rebecca Ford, Jason Hinds, Sophie La Vincente, Deborah Lehmann, Ruth Lim, Tuya Mungun, Paul N. Newton, Rattanaphone Phetsouvanh, Willam S. Pomat, Anonh Xeuatvongsa, Claire Von Mollendorf, David A.B. Dance & 3 others Catherine Satzke, Kim Muholland, Fiona M. Russell

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Introduction Pneumococcal conjugate vaccines (PCVs) prevent disease through both direct protection of vaccinated individuals and indirect protection of unvaccinated individuals by reducing nasopharyngeal (NP) carriage and transmission of vaccine-type (VT) pneumococci. While the indirect effects of PCV vaccination are well described, the PCV coverage required to achieve the indirect effects is unknown. We will investigate the relationship between PCV coverage and VT carriage among undervaccinated children using hospital-based NP pneumococcal carriage surveillance at three sites in Asia and the Pacific. Methods and analysis We are recruiting cases, defined as children aged 2-59 months admitted to participating hospitals with acute respiratory infection in Lao People's Democratic Republic, Mongolia and Papua New Guinea. Thirteen-valent PCV status is obtained from written records. NP swabs are collected according to standard methods, screened using lytA qPCR and serotyped by microarray. Village-level vaccination coverage, for the resident communities of the recruited cases, is determined using administrative data or community survey. Our analysis will investigate the relationship between VT carriage among undervaccinated cases (indirect effects) and vaccine coverage using generalised estimating equations. Ethics and dissemination Ethical approval has been obtained from the relevant ethics committees at participating sites. The results are intended for publication in open-access peer-reviewed journals and will demonstrate methods suitable for low- and middle-income countries to monitor vaccine impact and inform vaccine policy makers about the PCV coverage required to achieve indirect protection.

Original languageEnglish
Article numbere021512
JournalBMJ Open
Volume8
Issue number5
DOIs
Publication statusPublished - 1 May 2018

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Conjugate Vaccines
Pneumococcal Vaccines
Observational Studies
Vaccines
Prospective Studies
Vaccination
Mongolia
Laos
Papua New Guinea
Ethics Committees
Streptococcus pneumoniae
Administrative Personnel
Ethics
Respiratory Tract Infections
Publications

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Chan, Jocelyn ; Nguyen, Cattram D. ; Lai, Jana Y.R. ; Dunne, Eileen M. ; Andrews, Ross ; Blyth, Christopher C. ; Datta, Siddhartha ; Fox, Kim ; Ford, Rebecca ; Hinds, Jason ; La Vincente, Sophie ; Lehmann, Deborah ; Lim, Ruth ; Mungun, Tuya ; Newton, Paul N. ; Phetsouvanh, Rattanaphone ; Pomat, Willam S. ; Xeuatvongsa, Anonh ; Von Mollendorf, Claire ; Dance, David A.B. ; Satzke, Catherine ; Muholland, Kim ; Russell, Fiona M. / Determining the pneumococcal conjugate vaccine coverage required for indirect protection against vaccine-type pneumococcal carriage in low and middle-income countries : A protocol for a prospective observational study. In: BMJ Open. 2018 ; Vol. 8, No. 5.
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abstract = "Introduction Pneumococcal conjugate vaccines (PCVs) prevent disease through both direct protection of vaccinated individuals and indirect protection of unvaccinated individuals by reducing nasopharyngeal (NP) carriage and transmission of vaccine-type (VT) pneumococci. While the indirect effects of PCV vaccination are well described, the PCV coverage required to achieve the indirect effects is unknown. We will investigate the relationship between PCV coverage and VT carriage among undervaccinated children using hospital-based NP pneumococcal carriage surveillance at three sites in Asia and the Pacific. Methods and analysis We are recruiting cases, defined as children aged 2-59 months admitted to participating hospitals with acute respiratory infection in Lao People's Democratic Republic, Mongolia and Papua New Guinea. Thirteen-valent PCV status is obtained from written records. NP swabs are collected according to standard methods, screened using lytA qPCR and serotyped by microarray. Village-level vaccination coverage, for the resident communities of the recruited cases, is determined using administrative data or community survey. Our analysis will investigate the relationship between VT carriage among undervaccinated cases (indirect effects) and vaccine coverage using generalised estimating equations. Ethics and dissemination Ethical approval has been obtained from the relevant ethics committees at participating sites. The results are intended for publication in open-access peer-reviewed journals and will demonstrate methods suitable for low- and middle-income countries to monitor vaccine impact and inform vaccine policy makers about the PCV coverage required to achieve indirect protection.",
keywords = "public health, respiratory infections",
author = "Jocelyn Chan and Nguyen, {Cattram D.} and Lai, {Jana Y.R.} and Dunne, {Eileen M.} and Ross Andrews and Blyth, {Christopher C.} and Siddhartha Datta and Kim Fox and Rebecca Ford and Jason Hinds and {La Vincente}, Sophie and Deborah Lehmann and Ruth Lim and Tuya Mungun and Newton, {Paul N.} and Rattanaphone Phetsouvanh and Pomat, {Willam S.} and Anonh Xeuatvongsa and {Von Mollendorf}, Claire and Dance, {David A.B.} and Catherine Satzke and Kim Muholland and Russell, {Fiona M.}",
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Chan, J, Nguyen, CD, Lai, JYR, Dunne, EM, Andrews, R, Blyth, CC, Datta, S, Fox, K, Ford, R, Hinds, J, La Vincente, S, Lehmann, D, Lim, R, Mungun, T, Newton, PN, Phetsouvanh, R, Pomat, WS, Xeuatvongsa, A, Von Mollendorf, C, Dance, DAB, Satzke, C, Muholland, K & Russell, FM 2018, 'Determining the pneumococcal conjugate vaccine coverage required for indirect protection against vaccine-type pneumococcal carriage in low and middle-income countries: A protocol for a prospective observational study' BMJ Open, vol. 8, no. 5, e021512. https://doi.org/10.1136/bmjopen-2018-021512

Determining the pneumococcal conjugate vaccine coverage required for indirect protection against vaccine-type pneumococcal carriage in low and middle-income countries : A protocol for a prospective observational study. / Chan, Jocelyn; Nguyen, Cattram D.; Lai, Jana Y.R.; Dunne, Eileen M.; Andrews, Ross; Blyth, Christopher C.; Datta, Siddhartha; Fox, Kim; Ford, Rebecca; Hinds, Jason; La Vincente, Sophie; Lehmann, Deborah; Lim, Ruth; Mungun, Tuya; Newton, Paul N.; Phetsouvanh, Rattanaphone; Pomat, Willam S.; Xeuatvongsa, Anonh; Von Mollendorf, Claire; Dance, David A.B.; Satzke, Catherine; Muholland, Kim; Russell, Fiona M.

In: BMJ Open, Vol. 8, No. 5, e021512, 01.05.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Determining the pneumococcal conjugate vaccine coverage required for indirect protection against vaccine-type pneumococcal carriage in low and middle-income countries

T2 - A protocol for a prospective observational study

AU - Chan, Jocelyn

AU - Nguyen, Cattram D.

AU - Lai, Jana Y.R.

AU - Dunne, Eileen M.

AU - Andrews, Ross

AU - Blyth, Christopher C.

AU - Datta, Siddhartha

AU - Fox, Kim

AU - Ford, Rebecca

AU - Hinds, Jason

AU - La Vincente, Sophie

AU - Lehmann, Deborah

AU - Lim, Ruth

AU - Mungun, Tuya

AU - Newton, Paul N.

AU - Phetsouvanh, Rattanaphone

AU - Pomat, Willam S.

AU - Xeuatvongsa, Anonh

AU - Von Mollendorf, Claire

AU - Dance, David A.B.

AU - Satzke, Catherine

AU - Muholland, Kim

AU - Russell, Fiona M.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Introduction Pneumococcal conjugate vaccines (PCVs) prevent disease through both direct protection of vaccinated individuals and indirect protection of unvaccinated individuals by reducing nasopharyngeal (NP) carriage and transmission of vaccine-type (VT) pneumococci. While the indirect effects of PCV vaccination are well described, the PCV coverage required to achieve the indirect effects is unknown. We will investigate the relationship between PCV coverage and VT carriage among undervaccinated children using hospital-based NP pneumococcal carriage surveillance at three sites in Asia and the Pacific. Methods and analysis We are recruiting cases, defined as children aged 2-59 months admitted to participating hospitals with acute respiratory infection in Lao People's Democratic Republic, Mongolia and Papua New Guinea. Thirteen-valent PCV status is obtained from written records. NP swabs are collected according to standard methods, screened using lytA qPCR and serotyped by microarray. Village-level vaccination coverage, for the resident communities of the recruited cases, is determined using administrative data or community survey. Our analysis will investigate the relationship between VT carriage among undervaccinated cases (indirect effects) and vaccine coverage using generalised estimating equations. Ethics and dissemination Ethical approval has been obtained from the relevant ethics committees at participating sites. The results are intended for publication in open-access peer-reviewed journals and will demonstrate methods suitable for low- and middle-income countries to monitor vaccine impact and inform vaccine policy makers about the PCV coverage required to achieve indirect protection.

AB - Introduction Pneumococcal conjugate vaccines (PCVs) prevent disease through both direct protection of vaccinated individuals and indirect protection of unvaccinated individuals by reducing nasopharyngeal (NP) carriage and transmission of vaccine-type (VT) pneumococci. While the indirect effects of PCV vaccination are well described, the PCV coverage required to achieve the indirect effects is unknown. We will investigate the relationship between PCV coverage and VT carriage among undervaccinated children using hospital-based NP pneumococcal carriage surveillance at three sites in Asia and the Pacific. Methods and analysis We are recruiting cases, defined as children aged 2-59 months admitted to participating hospitals with acute respiratory infection in Lao People's Democratic Republic, Mongolia and Papua New Guinea. Thirteen-valent PCV status is obtained from written records. NP swabs are collected according to standard methods, screened using lytA qPCR and serotyped by microarray. Village-level vaccination coverage, for the resident communities of the recruited cases, is determined using administrative data or community survey. Our analysis will investigate the relationship between VT carriage among undervaccinated cases (indirect effects) and vaccine coverage using generalised estimating equations. Ethics and dissemination Ethical approval has been obtained from the relevant ethics committees at participating sites. The results are intended for publication in open-access peer-reviewed journals and will demonstrate methods suitable for low- and middle-income countries to monitor vaccine impact and inform vaccine policy makers about the PCV coverage required to achieve indirect protection.

KW - public health

KW - respiratory infections

UR - http://www.scopus.com/inward/record.url?scp=85050679595&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2018-021512

DO - 10.1136/bmjopen-2018-021512

M3 - Article

VL - 8

JO - BMJ (Open)

JF - BMJ (Open)

SN - 2044-6055

IS - 5

M1 - e021512

ER -