Desmoplastic melanoma: Recent advances and persisting challenges

    Research output: Contribution to journalReview article

    12 Citations (Scopus)

    Abstract

    Desmoplastic melanoma is an uncommon variant of melanoma which presents significant challenges to the clinician and histopathologist. In particular, many cases show a bland 'fibroblastic' appearance, mimicking scar and a range of other benign proliferations. This diagnosis can be particularly problematic in small biopsy specimens, a difficulty exacerbated by an immunoprofile which is typically negative for a number of conventional melanocytic markers. The clinical and histological features of desmoplastic melanoma are reviewed, as are the differential diagnoses and some newer techniques which may contribute to assessment of these lesions. In recent years it has become clear that subclassification of desmoplastic melanoma into pure and mixed variants has clinical significance and it is suggested that this classification be employed in routine practice. © 2013 Royal College of Pathologists of Australasia.
    Original languageEnglish
    Pages (from-to)453-463
    JournalPathology
    Volume45
    Issue number5
    DOIs
    Publication statusPublished - 2013

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    Melanoma
    Australasia
    Cicatrix
    Differential Diagnosis
    Biopsy

    Cite this

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    title = "Desmoplastic melanoma: Recent advances and persisting challenges",
    abstract = "Desmoplastic melanoma is an uncommon variant of melanoma which presents significant challenges to the clinician and histopathologist. In particular, many cases show a bland 'fibroblastic' appearance, mimicking scar and a range of other benign proliferations. This diagnosis can be particularly problematic in small biopsy specimens, a difficulty exacerbated by an immunoprofile which is typically negative for a number of conventional melanocytic markers. The clinical and histological features of desmoplastic melanoma are reviewed, as are the differential diagnoses and some newer techniques which may contribute to assessment of these lesions. In recent years it has become clear that subclassification of desmoplastic melanoma into pure and mixed variants has clinical significance and it is suggested that this classification be employed in routine practice. {\circledC} 2013 Royal College of Pathologists of Australasia.",
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    language = "English",
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    Desmoplastic melanoma: Recent advances and persisting challenges. / Wood, Benjamin.

    In: Pathology, Vol. 45, No. 5, 2013, p. 453-463.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Desmoplastic melanoma: Recent advances and persisting challenges

    AU - Wood, Benjamin

    PY - 2013

    Y1 - 2013

    N2 - Desmoplastic melanoma is an uncommon variant of melanoma which presents significant challenges to the clinician and histopathologist. In particular, many cases show a bland 'fibroblastic' appearance, mimicking scar and a range of other benign proliferations. This diagnosis can be particularly problematic in small biopsy specimens, a difficulty exacerbated by an immunoprofile which is typically negative for a number of conventional melanocytic markers. The clinical and histological features of desmoplastic melanoma are reviewed, as are the differential diagnoses and some newer techniques which may contribute to assessment of these lesions. In recent years it has become clear that subclassification of desmoplastic melanoma into pure and mixed variants has clinical significance and it is suggested that this classification be employed in routine practice. © 2013 Royal College of Pathologists of Australasia.

    AB - Desmoplastic melanoma is an uncommon variant of melanoma which presents significant challenges to the clinician and histopathologist. In particular, many cases show a bland 'fibroblastic' appearance, mimicking scar and a range of other benign proliferations. This diagnosis can be particularly problematic in small biopsy specimens, a difficulty exacerbated by an immunoprofile which is typically negative for a number of conventional melanocytic markers. The clinical and histological features of desmoplastic melanoma are reviewed, as are the differential diagnoses and some newer techniques which may contribute to assessment of these lesions. In recent years it has become clear that subclassification of desmoplastic melanoma into pure and mixed variants has clinical significance and it is suggested that this classification be employed in routine practice. © 2013 Royal College of Pathologists of Australasia.

    U2 - 10.1097/PAT.0b013e3283631c96

    DO - 10.1097/PAT.0b013e3283631c96

    M3 - Review article

    VL - 45

    SP - 453

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    JO - Pathology

    JF - Pathology

    SN - 0031-3025

    IS - 5

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