Dermatomyositis, polymyositis and immune-mediated necrotising myopathies

Yuebei Luo, Francis Mastaglia

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

© 2014 Elsevier B.V. Dermatomyositis, polymyositis and immune-mediated necrotising myopathy are major forms of idiopathic inflammatory myopathy. We review here recent developments in understanding the pathology and pathogenesis of these diseases, and characterisation of autoantibody biomarkers. Dermatomyositis is traditionally considered to be due to a complement-mediated microangiopathy but the factors responsible for complement activation remain uncertain. Recent studies have emphasised the importance of the type I interferon pathway in the pathogenesis of the disease and have identified autoantibodies with specificities for different clinical subgroups of patients. Polymyositis is characterised by a cytotoxic T cell response targeting as yet unidentified muscle antigens presented by MHC Class I molecules, and can occur in isolation but is more often part of a multi-systemic overlap syndrome. The immune-mediated necrotising myopathies are heterogeneous and are distinguished from polymyositis by the sparseness of inflammatory infiltrates and recognition of an association with specific autoantibodies such as anti-SRP and anti-HMGCR in many cases. This article is part of a Special Issue entitled: Neuromuscular Diseases: Pathology and Molecular Pathogenesis.
Original languageEnglish
Pages (from-to)622-632
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1852
Issue number4
DOIs
Publication statusPublished - 2015

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