Abstract
Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the required spectral detection hardware and halves the total scan time. Depth-encoded OCE may expedite clinical translation in time-sensitive applications requiring rapid 3D imaging of multiple tissue surfaces, such as tumor margin assessment in breast-conserving surgery.
| Original language | English |
|---|---|
| Pages (from-to) | 1233-1236 |
| Number of pages | 4 |
| Journal | Optics Letters |
| Volume | 42 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1 Apr 2017 |
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Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces. / Fang, Qi; Frewer, Luke; Wijesinghe, Philip; Allen, Wes M.; Chin, Lixin; Hamzah, Juliana; Sampson, David D.; Curatolo, Andrea; Kennedy, Brendan F.
In: Optics Letters, Vol. 42, No. 7, 01.04.2017, p. 1233-1236.Research output: Contribution to journal › Article
TY - JOUR
T1 - Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces
AU - Fang, Qi
AU - Frewer, Luke
AU - Wijesinghe, Philip
AU - Allen, Wes M.
AU - Chin, Lixin
AU - Hamzah, Juliana
AU - Sampson, David D.
AU - Curatolo, Andrea
AU - Kennedy, Brendan F.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the required spectral detection hardware and halves the total scan time. Depth-encoded OCE may expedite clinical translation in time-sensitive applications requiring rapid 3D imaging of multiple tissue surfaces, such as tumor margin assessment in breast-conserving surgery.
AB - Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the required spectral detection hardware and halves the total scan time. Depth-encoded OCE may expedite clinical translation in time-sensitive applications requiring rapid 3D imaging of multiple tissue surfaces, such as tumor margin assessment in breast-conserving surgery.
UR - http://www.scopus.com/inward/record.url?scp=85016544946&partnerID=8YFLogxK
U2 - 10.1364/OL.42.001233
DO - 10.1364/OL.42.001233
M3 - Article
VL - 42
SP - 1233
EP - 1236
JO - Optics Letters
JF - Optics Letters
SN - 0146-9592
IS - 7
ER -