Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces

Qi Fang, Luke Frewer, Philip Wijesinghe, Wes M. Allen, Lixin Chin, Juliana Hamzah, David D. Sampson, Andrea Curatolo, Brendan F. Kennedy

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the required spectral detection hardware and halves the total scan time. Depth-encoded OCE may expedite clinical translation in time-sensitive applications requiring rapid 3D imaging of multiple tissue surfaces, such as tumor margin assessment in breast-conserving surgery.

Original languageEnglish
Pages (from-to)1233-1236
Number of pages4
JournalOptics Letters
Volume42
Issue number7
DOIs
Publication statusPublished - 1 Apr 2017

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