Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces

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3 Citations (Scopus)

Abstract

Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the required spectral detection hardware and halves the total scan time. Depth-encoded OCE may expedite clinical translation in time-sensitive applications requiring rapid 3D imaging of multiple tissue surfaces, such as tumor margin assessment in breast-conserving surgery.

Original languageEnglish
Pages (from-to)1233-1236
Number of pages4
JournalOptics Letters
Volume42
Issue number7
DOIs
Publication statusPublished - 1 Apr 2017

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optical thickness
interferometers
carrier frequencies
silicones
liver
surgery
breast
mice
margins
acquisition
hardware
tumors
spectrometers

Cite this

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abstract = "Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the required spectral detection hardware and halves the total scan time. Depth-encoded OCE may expedite clinical translation in time-sensitive applications requiring rapid 3D imaging of multiple tissue surfaces, such as tumor margin assessment in breast-conserving surgery.",
author = "Qi Fang and Luke Frewer and Philip Wijesinghe and Allen, {Wes M.} and Lixin Chin and Juliana Hamzah and Sampson, {David D.} and Andrea Curatolo and Kennedy, {Brendan F.}",
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AU - Fang, Qi

AU - Frewer, Luke

AU - Wijesinghe, Philip

AU - Allen, Wes M.

AU - Chin, Lixin

AU - Hamzah, Juliana

AU - Sampson, David D.

AU - Curatolo, Andrea

AU - Kennedy, Brendan F.

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AB - Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the required spectral detection hardware and halves the total scan time. Depth-encoded OCE may expedite clinical translation in time-sensitive applications requiring rapid 3D imaging of multiple tissue surfaces, such as tumor margin assessment in breast-conserving surgery.

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