Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies

Qing-E Zhang; Fei Wang; Geng Qin; Wei Zheng; Chee H. Ng; Gabor S. Ungvari; Zhen Yuan; Songli Mei; Gang Wang; Yu-Tao Xiang

doi:10.7150/ijbs.25001

Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies

Qing-E Zhang, Fei Wang, Geng Qin, Wei Zheng, Chee H. Ng, Gabor S. Ungvari, Zhen Yuan, Songli Mei, Gang Wang, Yu-Tao Xiang

UWA Medical School

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Depression is common in patients with irritable bowel syndrome (IBS), but the reported prevalence across different studies is inconsistent. This meta-analysis systematically examined the presence and severity of depressive symptoms in patients with IBS. Two investigators independently performed a literature search. The pooled depressive symptom severity was calculated using a random effects model. Subgroup, sensitivity and meta-regression analyses were conducted to examine the moderating factors of the development of depressive symptoms. Twenty four studies (n=2,837) comparing depressive symptoms between IBS patients (n=1,775) and healthy controls (n=1,062) were identified; 14 (58.3%) studies were rated as high quality. Compared to healthy controls, IBS patients had more frequent (OR=9.21, 95% CI: 4.56-18.57, P

Original language	English
Pages (from-to)	1504-1512
Number of pages	9
Journal	International Journal of Biological Sciences
Volume	14
Issue number	11
DOIs	https://doi.org/10.7150/ijbs.25001
Publication status	Published - 15 Aug 2018

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10.7150/ijbs.25001Licence: CC BY-NC

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title = "Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies",

abstract = "Depression is common in patients with irritable bowel syndrome (IBS), but the reported prevalence across different studies is inconsistent. This meta-analysis systematically examined the presence and severity of depressive symptoms in patients with IBS. Two investigators independently performed a literature search. The pooled depressive symptom severity was calculated using a random effects model. Subgroup, sensitivity and meta-regression analyses were conducted to examine the moderating factors of the development of depressive symptoms. Twenty four studies (n=2,837) comparing depressive symptoms between IBS patients (n=1,775) and healthy controls (n=1,062) were identified; 14 (58.3%) studies were rated as high quality. Compared to healthy controls, IBS patients had more frequent (OR=9.21, 95% CI: 4.56-18.57, P",

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author = "Qing-E Zhang and Fei Wang and Geng Qin and Wei Zheng and Ng, {Chee H.} and Ungvari, {Gabor S.} and Zhen Yuan and Songli Mei and Gang Wang and Yu-Tao Xiang",

year = "2018",

month = aug,

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doi = "10.7150/ijbs.25001",

language = "English",

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journal = "International Journal of Biological Sciences",

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T1 - Depressive symptoms in patients with irritable bowel syndrome

T2 - a meta-analysis of comparative studies

AU - Zhang, Qing-E

AU - Wang, Fei

AU - Qin, Geng

AU - Zheng, Wei

AU - Ng, Chee H.

AU - Ungvari, Gabor S.

AU - Yuan, Zhen

AU - Mei, Songli

AU - Wang, Gang

AU - Xiang, Yu-Tao

PY - 2018/8/15

Y1 - 2018/8/15

N2 - Depression is common in patients with irritable bowel syndrome (IBS), but the reported prevalence across different studies is inconsistent. This meta-analysis systematically examined the presence and severity of depressive symptoms in patients with IBS. Two investigators independently performed a literature search. The pooled depressive symptom severity was calculated using a random effects model. Subgroup, sensitivity and meta-regression analyses were conducted to examine the moderating factors of the development of depressive symptoms. Twenty four studies (n=2,837) comparing depressive symptoms between IBS patients (n=1,775) and healthy controls (n=1,062) were identified; 14 (58.3%) studies were rated as high quality. Compared to healthy controls, IBS patients had more frequent (OR=9.21, 95% CI: 4.56-18.57, P

AB - Depression is common in patients with irritable bowel syndrome (IBS), but the reported prevalence across different studies is inconsistent. This meta-analysis systematically examined the presence and severity of depressive symptoms in patients with IBS. Two investigators independently performed a literature search. The pooled depressive symptom severity was calculated using a random effects model. Subgroup, sensitivity and meta-regression analyses were conducted to examine the moderating factors of the development of depressive symptoms. Twenty four studies (n=2,837) comparing depressive symptoms between IBS patients (n=1,775) and healthy controls (n=1,062) were identified; 14 (58.3%) studies were rated as high quality. Compared to healthy controls, IBS patients had more frequent (OR=9.21, 95% CI: 4.56-18.57, P

KW - IBS

KW - depressive symptoms

KW - controlled studies

KW - meta-analysis

KW - FUNCTIONAL GASTROINTESTINAL DISORDERS

KW - QUALITY-OF-LIFE

KW - RATING-SCALE

KW - DIAGNOSTIC-CRITERIA

KW - ANXIETY

KW - PREVALENCE

KW - HETEROGENEITY

KW - HEALTH

KW - WOMEN

KW - BIAS

U2 - 10.7150/ijbs.25001

DO - 10.7150/ijbs.25001

M3 - Article

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VL - 14

SP - 1504

EP - 1512

JO - International Journal of Biological Sciences

JF - International Journal of Biological Sciences

IS - 11

ER -

Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies

Abstract

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