Deposition of non-porous calcium phosphate shells onto liquid filled microcapsules

Alison L. White, Hazel A. Javier, Sarah Withey, Simon R. Biggs, Stephen Rose, Simon G. Puttick, Andrew K. Whittaker

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The efficient encapsulation of small molecule active ingredients has been a challenge for many decades across many commercial applications. Recently, successful attempts to address this issue have included deposition of thin metal shells onto liquid filled polymer microcapsules or emulsion droplets to provide an impermeable barrier to diffusion. In this work we have developed a novel method to protect small molecule active ingredients by deposition of thin mineral shells. Platinum nanoparticles are used to catalyse and direct growth of a calcium phosphate shell onto liquid filled polymer microcapsules under various reaction conditions. Findings indicate that a non-porous protective shell is formed on the majority of the microcapsule population, with small concentrations of the core material being released only from those microcapsules with defects, over a 7 days period, when conducting forced release studies into a solvent for the core oil. The resulting microcapsules show no significant cell toxicity when exposed to HEK 293 cells for 72 h.

Original languageEnglish
Pages (from-to)575-583
Number of pages9
JournalJournal of Colloid and Interface Science
Volume609
Early online date15 Nov 2021
DOIs
Publication statusPublished - Mar 2022

Fingerprint

Dive into the research topics of 'Deposition of non-porous calcium phosphate shells onto liquid filled microcapsules'. Together they form a unique fingerprint.

Cite this