TY - JOUR
T1 - Dendronised Polymers as Templates for In Situ Quantum Dot Synthesis
AU - Munshi, Alaa M.
AU - Kretzmann, Jessica A.
AU - Evans, Cameron W.
AU - Ranieri, Anna M.
AU - Schildkraut, Zibeon
AU - Massi, Massimiliano
AU - Norret, Marck
AU - Saunders, Martin
AU - Iyer, K. Swaminathan
PY - 2020/7
Y1 - 2020/7
N2 - The utility of dendrimers as effective carriers for targeted drug delivery and imaging has been facilitated by a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, and multivalency. Dendrimer-quantum dot (QD) nanocomposites have traditionally been synthesised by electrostatic self-assembly of preformed dendrimers and QDs, but higher generations are associated with limited flexibility and increased cytotoxicity. In this paper, we report the fabrication of CdTe QD nanoparticles using a dendronised linear copolymer bearing thiolated fourth-generation poly(amido amine) (PAMAM) dendrons as the capping and stabilising agent. We demonstrate this approach enables synthesis of nanocomposites with aqueous and photophysical stability. © 2020 CSIRO.
AB - The utility of dendrimers as effective carriers for targeted drug delivery and imaging has been facilitated by a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, and multivalency. Dendrimer-quantum dot (QD) nanocomposites have traditionally been synthesised by electrostatic self-assembly of preformed dendrimers and QDs, but higher generations are associated with limited flexibility and increased cytotoxicity. In this paper, we report the fabrication of CdTe QD nanoparticles using a dendronised linear copolymer bearing thiolated fourth-generation poly(amido amine) (PAMAM) dendrons as the capping and stabilising agent. We demonstrate this approach enables synthesis of nanocomposites with aqueous and photophysical stability. © 2020 CSIRO.
UR - http://www.scopus.com/inward/record.url?scp=85090621404&partnerID=8YFLogxK
U2 - 10.1071/CH20071
DO - 10.1071/CH20071
M3 - Article
SN - 0004-9425
VL - 73
SP - 658
EP - 663
JO - Australian Journal of Chemistry
JF - Australian Journal of Chemistry
IS - 7
ER -