Dendritic Relationships between Cholinergic Amacrine Cells and Direction-Selective Retinal Ganglion Cells

Shaun Patrick Collin, David I. Vaney, Heather M. Young

    Research output: Chapter in Book/Conference paperChapter

    Abstract

    Although the apparent simplicity of direction selectivity has fascinated retinal physiologists since the process was first characterized by Barlow & Levick (1965), its synaptic mechanism still eludes us. There is substantial cholinergic input to direction-selective (DS) retinal ganglion cells (Masland & Ames 1976, Ariel & Daw 1982) but the functions of cholinergic amacrine cells in complex visual processing are poorly understood. Direction selectivity is believed to arise from non-linear interactions between cholinergic and GABAergic inputs, either in the ganglion cell itself or at a presynaptic level. The recent finding that the cholinergic amacrines also contain γ-aminobutyric acid (GABA; Vaney & Young 1988) and its synthetic enzyme (GAD; Kosaka et al 1988, Brecha et al 1988), is compatible with a single type of interneuron mediating both the excitation and inhibition to DS ganglion cells (Dowling 1970).
    Original languageEnglish
    Title of host publicationNeurobiology of the Inner Retina
    Subtitle of host publicationNATO ASI Series (Series H: Cell Biology)
    PublisherSpringer, Berlin, Heidelberg
    Pages157
    Number of pages168
    Volume31
    ISBN (Electronic)978-3-642-74149-4
    ISBN (Print)978-3-642-74151-7
    DOIs
    Publication statusPublished - 1989

    Fingerprint

    Amacrine Cells
    Retinal Ganglion Cells
    Cholinergic Agents
    Ganglia
    Aminobutyrates
    Interneurons
    gamma-Aminobutyric Acid
    Direction compound
    Enzymes

    Cite this

    Collin, S. P., Vaney, D. I., & Young, H. M. (1989). Dendritic Relationships between Cholinergic Amacrine Cells and Direction-Selective Retinal Ganglion Cells. In Neurobiology of the Inner Retina: NATO ASI Series (Series H: Cell Biology) (Vol. 31, pp. 157). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74149-4_13
    Collin, Shaun Patrick ; Vaney, David I. ; Young, Heather M. / Dendritic Relationships between Cholinergic Amacrine Cells and Direction-Selective Retinal Ganglion Cells. Neurobiology of the Inner Retina: NATO ASI Series (Series H: Cell Biology). Vol. 31 Springer, Berlin, Heidelberg, 1989. pp. 157
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    abstract = "Although the apparent simplicity of direction selectivity has fascinated retinal physiologists since the process was first characterized by Barlow & Levick (1965), its synaptic mechanism still eludes us. There is substantial cholinergic input to direction-selective (DS) retinal ganglion cells (Masland & Ames 1976, Ariel & Daw 1982) but the functions of cholinergic amacrine cells in complex visual processing are poorly understood. Direction selectivity is believed to arise from non-linear interactions between cholinergic and GABAergic inputs, either in the ganglion cell itself or at a presynaptic level. The recent finding that the cholinergic amacrines also contain γ-aminobutyric acid (GABA; Vaney & Young 1988) and its synthetic enzyme (GAD; Kosaka et al 1988, Brecha et al 1988), is compatible with a single type of interneuron mediating both the excitation and inhibition to DS ganglion cells (Dowling 1970).",
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    Collin, SP, Vaney, DI & Young, HM 1989, Dendritic Relationships between Cholinergic Amacrine Cells and Direction-Selective Retinal Ganglion Cells. in Neurobiology of the Inner Retina: NATO ASI Series (Series H: Cell Biology). vol. 31, Springer, Berlin, Heidelberg, pp. 157. https://doi.org/10.1007/978-3-642-74149-4_13

    Dendritic Relationships between Cholinergic Amacrine Cells and Direction-Selective Retinal Ganglion Cells. / Collin, Shaun Patrick; Vaney, David I.; Young, Heather M.

    Neurobiology of the Inner Retina: NATO ASI Series (Series H: Cell Biology). Vol. 31 Springer, Berlin, Heidelberg, 1989. p. 157.

    Research output: Chapter in Book/Conference paperChapter

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    N2 - Although the apparent simplicity of direction selectivity has fascinated retinal physiologists since the process was first characterized by Barlow & Levick (1965), its synaptic mechanism still eludes us. There is substantial cholinergic input to direction-selective (DS) retinal ganglion cells (Masland & Ames 1976, Ariel & Daw 1982) but the functions of cholinergic amacrine cells in complex visual processing are poorly understood. Direction selectivity is believed to arise from non-linear interactions between cholinergic and GABAergic inputs, either in the ganglion cell itself or at a presynaptic level. The recent finding that the cholinergic amacrines also contain γ-aminobutyric acid (GABA; Vaney & Young 1988) and its synthetic enzyme (GAD; Kosaka et al 1988, Brecha et al 1988), is compatible with a single type of interneuron mediating both the excitation and inhibition to DS ganglion cells (Dowling 1970).

    AB - Although the apparent simplicity of direction selectivity has fascinated retinal physiologists since the process was first characterized by Barlow & Levick (1965), its synaptic mechanism still eludes us. There is substantial cholinergic input to direction-selective (DS) retinal ganglion cells (Masland & Ames 1976, Ariel & Daw 1982) but the functions of cholinergic amacrine cells in complex visual processing are poorly understood. Direction selectivity is believed to arise from non-linear interactions between cholinergic and GABAergic inputs, either in the ganglion cell itself or at a presynaptic level. The recent finding that the cholinergic amacrines also contain γ-aminobutyric acid (GABA; Vaney & Young 1988) and its synthetic enzyme (GAD; Kosaka et al 1988, Brecha et al 1988), is compatible with a single type of interneuron mediating both the excitation and inhibition to DS ganglion cells (Dowling 1970).

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    Collin SP, Vaney DI, Young HM. Dendritic Relationships between Cholinergic Amacrine Cells and Direction-Selective Retinal Ganglion Cells. In Neurobiology of the Inner Retina: NATO ASI Series (Series H: Cell Biology). Vol. 31. Springer, Berlin, Heidelberg. 1989. p. 157 https://doi.org/10.1007/978-3-642-74149-4_13