Dendritic maturation of displaced putative cholinergic amacrine cells in the rabbit retina

Shaun Patrick Collin, Rachel O. Wong

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Abstract

    The dendritic trees of Cb, cholinergic, amacrine cells in the ganglion cell layer of the developing rabbit retina are revealed by intracellular injection with Lucifer yellow to have the adult dendritic branching pattern at birth. It is demonstrated that these cells maintain a constant number of dendritic branches throughout postnatal development and that their dendritic trees increase in size by the growth and subsequent elongation of all branches. Proximal and distal dendrites increase in length by almost the same proportions between birth and adulthood.

    Although the adult pattern of dendritic branching of Cb amacrine cells is established by birth, dendrities in the young possess numerous short appendages (1–5 μm in length) resembling the “dendritic spines” of immature cat retinal ganglion cells. Some of these structures remain on the dendrites of adult cells but the majority are lost at the end of the third postnatal week. As dendritic spines disappear, the dendrites of Cb amacrine cells, especially the distal portion of the tree, acquire numerous varicosities. At each stage after P10, the gain in the number of varicosities greatly exceeds the loss in spines; this is not consistent with the hypothesis that all varicosities are retracted dendritic spines. The rapid increase in the number of varicosities on distal dendrites of Cb amacrine cells during the first 3 postnatal weeks coincides with the maturation of amacrine cell physiological responses.

    There is no distinct centroperipheral gradient in the postnatal dendritic maturation (acquisition of varicosities, loss of spines, attainment of the adult number of branches) of Cb amacrine cells from the visual streak to the peripheral retina. However, the area of their dendritic tree increases relatively more in the retinal periphery compared to that in the visual streak.
    Original languageEnglish
    Pages (from-to)164-178
    Number of pages14
    JournalThe Journal of Comparative Neurology
    Volume287
    Issue number2
    DOIs
    Publication statusPublished - 8 Sep 1989

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    Amacrine Cells
    Cholinergic Agents
    Retina
    Dendrites
    Rabbits
    Dendritic Spines
    Parturition
    Spine
    Retinal Ganglion Cells
    Ganglia
    Cats
    Injections
    Growth

    Cite this

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    title = "Dendritic maturation of displaced putative cholinergic amacrine cells in the rabbit retina",
    abstract = "The dendritic trees of Cb, cholinergic, amacrine cells in the ganglion cell layer of the developing rabbit retina are revealed by intracellular injection with Lucifer yellow to have the adult dendritic branching pattern at birth. It is demonstrated that these cells maintain a constant number of dendritic branches throughout postnatal development and that their dendritic trees increase in size by the growth and subsequent elongation of all branches. Proximal and distal dendrites increase in length by almost the same proportions between birth and adulthood.Although the adult pattern of dendritic branching of Cb amacrine cells is established by birth, dendrities in the young possess numerous short appendages (1–5 μm in length) resembling the “dendritic spines” of immature cat retinal ganglion cells. Some of these structures remain on the dendrites of adult cells but the majority are lost at the end of the third postnatal week. As dendritic spines disappear, the dendrites of Cb amacrine cells, especially the distal portion of the tree, acquire numerous varicosities. At each stage after P10, the gain in the number of varicosities greatly exceeds the loss in spines; this is not consistent with the hypothesis that all varicosities are retracted dendritic spines. The rapid increase in the number of varicosities on distal dendrites of Cb amacrine cells during the first 3 postnatal weeks coincides with the maturation of amacrine cell physiological responses.There is no distinct centroperipheral gradient in the postnatal dendritic maturation (acquisition of varicosities, loss of spines, attainment of the adult number of branches) of Cb amacrine cells from the visual streak to the peripheral retina. However, the area of their dendritic tree increases relatively more in the retinal periphery compared to that in the visual streak.",
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    Dendritic maturation of displaced putative cholinergic amacrine cells in the rabbit retina. / Collin, Shaun Patrick; Wong, Rachel O.

    In: The Journal of Comparative Neurology, Vol. 287, No. 2, 08.09.1989, p. 164-178.

    Research output: Contribution to journalArticle

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