Defective cell migration as a mechanism of dysregulated asthmatic airway repair

Research output: ThesisDoctoral Thesis

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Abstract

The airway epithelium of children with asthma is characterised by abnormal wound repair that may contribute to disease pathobiology. This thesis reports defective cell migration compromises asthmatic airway epithelial repair. One of the contributing mechanisms was reduced integrin a5111 expression that resulted in dysregulated migration and defective repair in cultures of asthmatic children. Furthermore, Notch signalling was shown to be dysregulated in the asthmatic airway epithelium and partially regulate integrin a5 and repair. Finally, RNA-Sequencing identified a multitude of pathways to be altered in asthma with therapeutic potential to direct future research into novel therapeutics targeting asthmatic airway epithelial restitution.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Kicic, Anthony, Supervisor
  • Stick, Stephen, Supervisor
  • Sutanto, Erika, Supervisor
  • Devadason, Sunalene, Supervisor
Thesis sponsors
Award date11 Jul 2018
DOIs
Publication statusUnpublished - 2017

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