TY - JOUR
T1 - Decreased interleukin-1beta and elastase in the gingival crevicular fluid of individuals undergoing anti-inflammatory treatment for rheumatoid arthritis
AU - Miranda, Letícia A
AU - Islabão, Alexandre G
AU - Fischer, Ricardo G
AU - Figueredo, Carlos M S
AU - Oppermann, Rui V
AU - Gustafsson, Anders
PY - 2007/8
Y1 - 2007/8
N2 - BACKGROUND: The primary aim of this study was to compare the inflammatory activity in the gingival crevicular fluid (GCF) in a group of patients with rheumatoid arthritis (RA) and a group of matched controls. Secondarily, we aimed to evaluate the effect of rheumatologic treatment on periodontal inflammation.METHODS: Seventeen individuals with RA with a mean duration of disease of 12.1 (+/- 9.9) years and the same number of systemically healthy individuals matched for age, gender, periodontal status, and tobacco use were selected. Medication data were registered, and GCF was collected by means of an intracrevicular washing method. Besides clinical registrations, periodontal inflammation was assessed by analysis of the cytokines interleukin (IL)-1beta and -18 and of elastase activity.RESULTS: Amounts of IL-1beta and total elastase were significantly lower in the patient group. IL-1beta and total elastase had a significant and strong correlation in the RA group (r(s) = 0.883). This correlation was not observed in the control group.CONCLUSION: The anti-inflammatory treatment taken by RA patients might influence the periodontal inflammation status represented by IL-1beta and elastase in the GCF.
AB - BACKGROUND: The primary aim of this study was to compare the inflammatory activity in the gingival crevicular fluid (GCF) in a group of patients with rheumatoid arthritis (RA) and a group of matched controls. Secondarily, we aimed to evaluate the effect of rheumatologic treatment on periodontal inflammation.METHODS: Seventeen individuals with RA with a mean duration of disease of 12.1 (+/- 9.9) years and the same number of systemically healthy individuals matched for age, gender, periodontal status, and tobacco use were selected. Medication data were registered, and GCF was collected by means of an intracrevicular washing method. Besides clinical registrations, periodontal inflammation was assessed by analysis of the cytokines interleukin (IL)-1beta and -18 and of elastase activity.RESULTS: Amounts of IL-1beta and total elastase were significantly lower in the patient group. IL-1beta and total elastase had a significant and strong correlation in the RA group (r(s) = 0.883). This correlation was not observed in the control group.CONCLUSION: The anti-inflammatory treatment taken by RA patients might influence the periodontal inflammation status represented by IL-1beta and elastase in the GCF.
KW - Acetaminophen/therapeutic use
KW - Anti-Inflammatory Agents/therapeutic use
KW - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
KW - Arthritis, Rheumatoid/drug therapy
KW - Case-Control Studies
KW - Cross-Sectional Studies
KW - Dental Plaque Index
KW - Female
KW - Gingival Crevicular Fluid/chemistry
KW - Gingival Hemorrhage/classification
KW - Humans
KW - Interleukin-18/analysis
KW - Interleukin-1beta/analysis
KW - Male
KW - Middle Aged
KW - Pancreatic Elastase/analysis
KW - Periodontal Attachment Loss/classification
KW - Periodontal Index
KW - Periodontal Pocket/classification
KW - Periodontitis/classification
KW - Prednisone/therapeutic use
KW - Smoking
U2 - 10.1902/jop.2007.060520
DO - 10.1902/jop.2007.060520
M3 - Article
C2 - 17668981
VL - 78
SP - 1612
EP - 1619
JO - Journal of Periodontology
JF - Journal of Periodontology
SN - 0022-3492
IS - 8
ER -