Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases

Tiphaine C. Martin, Mirna Šimurina, Marta Zabczynska, Marina Kavur, Magdalena Rydlewska, Marija Pezer, Kamila Kozłowska, Andrea Burri, Marija Vilaj, Renata Turek-Jabrocka, Milena Krnjajić-Tadijanović, Małgorzata Trofimiuk-Müldner, Ivo Ugrina, Anna Lityn, Alicja Hubalewska-Dydejczyk, Irena Trbojevic-Akmacic, Ee Mun Lim, John P. Walsh, Ewa Pocheć, Tim D. SpectorScott G. Wilson, Gordan Lauc

Research output: Contribution to journalArticle

Abstract

Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells glycosylation with AITD and the influence of genetic background in a case-control study with several independent cohorts and over 3,000 individuals in total. The study revealed an inverse association of IgG core fucosylation with TPOAb and AITD, as well as decreased peripheral blood mononuclear cells antennary α1,2 fucosylation in AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody-dependent cell-mediated cytotoxicity previously associated with TPOAb levels.

Original languageEnglish
Pages (from-to)774-792
Number of pages19
JournalMolecular and Cellular Proteomics
Volume19
Issue number5
DOIs
Publication statusPublished - 1 May 2020

Fingerprint Dive into the research topics of 'Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases'. Together they form a unique fingerprint.

  • Cite this

    Martin, T. C., Šimurina, M., Zabczynska, M., Kavur, M., Rydlewska, M., Pezer, M., Kozłowska, K., Burri, A., Vilaj, M., Turek-Jabrocka, R., Krnjajić-Tadijanović, M., Trofimiuk-Müldner, M., Ugrina, I., Lityn, A., Hubalewska-Dydejczyk, A., Trbojevic-Akmacic, I., Lim, E. M., Walsh, J. P., Pocheć, E., ... Lauc, G. (2020). Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases. Molecular and Cellular Proteomics, 19(5), 774-792. https://doi.org/10.1074/mcp.RA119.001860