DDT exposure in early childhood and female breast cancer: Evidence from an ecological study in Taiwan

Simon Chang, Sonia El-Zaemey, Jane Heyworth, Meng chi Tang

Research output: Contribution to journalArticle

Abstract

Researchers still lack consensus on the association between exposure to DDT and the risk of breast cancer. One reason could be that the measurements of DDT obtained during or near the time of diagnosis may not reflect exposure during the etiologically relevant time period in a woman's life. This study undertook an ecological analysis to investigate whether exposure to DDT among cohort born between 1951 and 1959 (i.e. age 0–5 years) and who reached the age 50–54 years during 2001–2013 had an increased risk of breast cancer in adulthood. To do this, we used the number of DDT sprays in each township during the anti-malaria campaign in Taiwan in the 1950s as a proxy for direct DDT exposure. The DDT sprays were then linked to the township female breast cancer incidence rate in the 2000s when the birth cohorts had reached age 50–54 years. Insurance claims data were used to identify breast cancer cases during 1996–2013. Zero-Inflated Poisson regression was performed to estimate the effect of DDT sprays on the breast cancer incidence rate. The analysis was based on a total of 9 birth cohorts (1951–1959) in 349 townships who had lived at least up to age 50. On average, one DDT spray experienced during age 0–5 years was associated with an increase of 8 more female breast cancer cases per 100,000 during age 50–54. The effect appears to increase with the number of sprays. Our finding suggests that DDT exposure in early childhood could raise the risk of breast cancer in adulthood.

Original languageEnglish
Pages (from-to)1106-1112
Number of pages7
JournalEnvironment International
Volume121
DOIs
Publication statusPublished - 1 Dec 2018

Fingerprint

DDT
cancer
spray
exposure
malaria

Cite this

@article{a02be5995845478e9bee1e7a7136d0e6,
title = "DDT exposure in early childhood and female breast cancer: Evidence from an ecological study in Taiwan",
abstract = "Researchers still lack consensus on the association between exposure to DDT and the risk of breast cancer. One reason could be that the measurements of DDT obtained during or near the time of diagnosis may not reflect exposure during the etiologically relevant time period in a woman's life. This study undertook an ecological analysis to investigate whether exposure to DDT among cohort born between 1951 and 1959 (i.e. age 0–5 years) and who reached the age 50–54 years during 2001–2013 had an increased risk of breast cancer in adulthood. To do this, we used the number of DDT sprays in each township during the anti-malaria campaign in Taiwan in the 1950s as a proxy for direct DDT exposure. The DDT sprays were then linked to the township female breast cancer incidence rate in the 2000s when the birth cohorts had reached age 50–54 years. Insurance claims data were used to identify breast cancer cases during 1996–2013. Zero-Inflated Poisson regression was performed to estimate the effect of DDT sprays on the breast cancer incidence rate. The analysis was based on a total of 9 birth cohorts (1951–1959) in 349 townships who had lived at least up to age 50. On average, one DDT spray experienced during age 0–5 years was associated with an increase of 8 more female breast cancer cases per 100,000 during age 50–54. The effect appears to increase with the number of sprays. Our finding suggests that DDT exposure in early childhood could raise the risk of breast cancer in adulthood.",
keywords = "Breast Cancer, DDT, Early childhood, Exposure",
author = "Simon Chang and Sonia El-Zaemey and Jane Heyworth and Tang, {Meng chi}",
year = "2018",
month = "12",
day = "1",
doi = "10.1016/j.envint.2018.10.023",
language = "English",
volume = "121",
pages = "1106--1112",
journal = "Environment International",
issn = "0160-4120",
publisher = "Pergamon",

}

DDT exposure in early childhood and female breast cancer : Evidence from an ecological study in Taiwan. / Chang, Simon; El-Zaemey, Sonia; Heyworth, Jane; Tang, Meng chi.

In: Environment International, Vol. 121, 01.12.2018, p. 1106-1112.

Research output: Contribution to journalArticle

TY - JOUR

T1 - DDT exposure in early childhood and female breast cancer

T2 - Evidence from an ecological study in Taiwan

AU - Chang, Simon

AU - El-Zaemey, Sonia

AU - Heyworth, Jane

AU - Tang, Meng chi

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Researchers still lack consensus on the association between exposure to DDT and the risk of breast cancer. One reason could be that the measurements of DDT obtained during or near the time of diagnosis may not reflect exposure during the etiologically relevant time period in a woman's life. This study undertook an ecological analysis to investigate whether exposure to DDT among cohort born between 1951 and 1959 (i.e. age 0–5 years) and who reached the age 50–54 years during 2001–2013 had an increased risk of breast cancer in adulthood. To do this, we used the number of DDT sprays in each township during the anti-malaria campaign in Taiwan in the 1950s as a proxy for direct DDT exposure. The DDT sprays were then linked to the township female breast cancer incidence rate in the 2000s when the birth cohorts had reached age 50–54 years. Insurance claims data were used to identify breast cancer cases during 1996–2013. Zero-Inflated Poisson regression was performed to estimate the effect of DDT sprays on the breast cancer incidence rate. The analysis was based on a total of 9 birth cohorts (1951–1959) in 349 townships who had lived at least up to age 50. On average, one DDT spray experienced during age 0–5 years was associated with an increase of 8 more female breast cancer cases per 100,000 during age 50–54. The effect appears to increase with the number of sprays. Our finding suggests that DDT exposure in early childhood could raise the risk of breast cancer in adulthood.

AB - Researchers still lack consensus on the association between exposure to DDT and the risk of breast cancer. One reason could be that the measurements of DDT obtained during or near the time of diagnosis may not reflect exposure during the etiologically relevant time period in a woman's life. This study undertook an ecological analysis to investigate whether exposure to DDT among cohort born between 1951 and 1959 (i.e. age 0–5 years) and who reached the age 50–54 years during 2001–2013 had an increased risk of breast cancer in adulthood. To do this, we used the number of DDT sprays in each township during the anti-malaria campaign in Taiwan in the 1950s as a proxy for direct DDT exposure. The DDT sprays were then linked to the township female breast cancer incidence rate in the 2000s when the birth cohorts had reached age 50–54 years. Insurance claims data were used to identify breast cancer cases during 1996–2013. Zero-Inflated Poisson regression was performed to estimate the effect of DDT sprays on the breast cancer incidence rate. The analysis was based on a total of 9 birth cohorts (1951–1959) in 349 townships who had lived at least up to age 50. On average, one DDT spray experienced during age 0–5 years was associated with an increase of 8 more female breast cancer cases per 100,000 during age 50–54. The effect appears to increase with the number of sprays. Our finding suggests that DDT exposure in early childhood could raise the risk of breast cancer in adulthood.

KW - Breast Cancer

KW - DDT

KW - Early childhood

KW - Exposure

UR - http://www.scopus.com/inward/record.url?scp=85055657450&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2018.10.023

DO - 10.1016/j.envint.2018.10.023

M3 - Article

VL - 121

SP - 1106

EP - 1112

JO - Environment International

JF - Environment International

SN - 0160-4120

ER -