DAT1 Gene Polymorphism in Alcoholism: A Family-Based Association Study

P. Franke, S.G. Schwab, M. Knapp, M. Gansicke, C. Delmo, P. Zill, M. Trixler, D. Lichtermann, J. Hallmayer, D.B. Wildenauer, W. Maier

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    Abstract

    Background: The present study tests the hypothesis that the 9-repeat allele of the dopamine transporter gene (DAT1 SLC6A3) is more frequent in alcohol-dependent probands-and in particular those with severe withdrawal symptoms (seizures and/or delirium)-compared to nonalcoholics.Methods: To avoid stratification effects, the family-based association approach of Falk and Rubinstein was used in our sample of 87 alcohol-dependent probands and their biological parents.Results: By applying a family-based association approach, we were not able to detect significant association between allele 9 at DAT1 (SLC6A3) and alcoholism as well as between patients with or without severe withdrawal symptoms.Conclusions: Based on our data, the impact of the 9-repeat allele of the dopamine transporter gene in alcoholism and the severity of alcohol withdrawal symptoms is putatively not substantial. Biol Psychiatry 1999;45:652-654 (C) 1999 Society of Biological Psychiatry.
    Original languageEnglish
    Pages (from-to)652-654
    JournalBiological Psychiatry
    Volume45
    Issue number5
    DOIs
    Publication statusPublished - 1999

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