DAT1 Gene Polymorphism in Alcoholism: A Family-Based Association Study

P. Franke; S.G. Schwab; M. Knapp; M. Gansicke; C. Delmo; P. Zill; M. Trixler; D. Lichtermann; J. Hallmayer; D.B. Wildenauer; W. Maier

doi:10.1016/S0006-3223(98)00135-8

DAT1 Gene Polymorphism in Alcoholism: A Family-Based Association Study

P. Franke, S.G. Schwab, M. Knapp, M. Gansicke, C. Delmo, P. Zill, M. Trixler, D. Lichtermann, J. Hallmayer, D.B. Wildenauer, W. Maier

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: The present study tests the hypothesis that the 9-repeat allele of the dopamine transporter gene (DAT1 SLC6A3) is more frequent in alcohol-dependent probands-and in particular those with severe withdrawal symptoms (seizures and/or delirium)-compared to nonalcoholics.Methods: To avoid stratification effects, the family-based association approach of Falk and Rubinstein was used in our sample of 87 alcohol-dependent probands and their biological parents.Results: By applying a family-based association approach, we were not able to detect significant association between allele 9 at DAT1 (SLC6A3) and alcoholism as well as between patients with or without severe withdrawal symptoms.Conclusions: Based on our data, the impact of the 9-repeat allele of the dopamine transporter gene in alcoholism and the severity of alcohol withdrawal symptoms is putatively not substantial. Biol Psychiatry 1999;45:652-654 (C) 1999 Society of Biological Psychiatry.

Original language	English
Pages (from-to)	652-654
Journal	Biological Psychiatry
Volume	45
Issue number	5
DOIs	https://doi.org/10.1016/S0006-3223(98)00135-8
Publication status	Published - 1999

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title = "DAT1 Gene Polymorphism in Alcoholism: A Family-Based Association Study",

abstract = "Background: The present study tests the hypothesis that the 9-repeat allele of the dopamine transporter gene (DAT1 SLC6A3) is more frequent in alcohol-dependent probands-and in particular those with severe withdrawal symptoms (seizures and/or delirium)-compared to nonalcoholics.Methods: To avoid stratification effects, the family-based association approach of Falk and Rubinstein was used in our sample of 87 alcohol-dependent probands and their biological parents.Results: By applying a family-based association approach, we were not able to detect significant association between allele 9 at DAT1 (SLC6A3) and alcoholism as well as between patients with or without severe withdrawal symptoms.Conclusions: Based on our data, the impact of the 9-repeat allele of the dopamine transporter gene in alcoholism and the severity of alcohol withdrawal symptoms is putatively not substantial. Biol Psychiatry 1999;45:652-654 (C) 1999 Society of Biological Psychiatry.",

author = "P. Franke and S.G. Schwab and M. Knapp and M. Gansicke and C. Delmo and P. Zill and M. Trixler and D. Lichtermann and J. Hallmayer and D.B. Wildenauer and W. Maier",

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doi = "10.1016/S0006-3223(98)00135-8",

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pages = "652--654",

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issn = "0006-3223",

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TY - JOUR

T1 - DAT1 Gene Polymorphism in Alcoholism: A Family-Based Association Study

AU - Franke, P.

AU - Schwab, S.G.

AU - Knapp, M.

AU - Gansicke, M.

AU - Delmo, C.

AU - Zill, P.

AU - Trixler, M.

AU - Lichtermann, D.

AU - Hallmayer, J.

AU - Wildenauer, D.B.

AU - Maier, W.

PY - 1999

Y1 - 1999

N2 - Background: The present study tests the hypothesis that the 9-repeat allele of the dopamine transporter gene (DAT1 SLC6A3) is more frequent in alcohol-dependent probands-and in particular those with severe withdrawal symptoms (seizures and/or delirium)-compared to nonalcoholics.Methods: To avoid stratification effects, the family-based association approach of Falk and Rubinstein was used in our sample of 87 alcohol-dependent probands and their biological parents.Results: By applying a family-based association approach, we were not able to detect significant association between allele 9 at DAT1 (SLC6A3) and alcoholism as well as between patients with or without severe withdrawal symptoms.Conclusions: Based on our data, the impact of the 9-repeat allele of the dopamine transporter gene in alcoholism and the severity of alcohol withdrawal symptoms is putatively not substantial. Biol Psychiatry 1999;45:652-654 (C) 1999 Society of Biological Psychiatry.

AB - Background: The present study tests the hypothesis that the 9-repeat allele of the dopamine transporter gene (DAT1 SLC6A3) is more frequent in alcohol-dependent probands-and in particular those with severe withdrawal symptoms (seizures and/or delirium)-compared to nonalcoholics.Methods: To avoid stratification effects, the family-based association approach of Falk and Rubinstein was used in our sample of 87 alcohol-dependent probands and their biological parents.Results: By applying a family-based association approach, we were not able to detect significant association between allele 9 at DAT1 (SLC6A3) and alcoholism as well as between patients with or without severe withdrawal symptoms.Conclusions: Based on our data, the impact of the 9-repeat allele of the dopamine transporter gene in alcoholism and the severity of alcohol withdrawal symptoms is putatively not substantial. Biol Psychiatry 1999;45:652-654 (C) 1999 Society of Biological Psychiatry.

U2 - 10.1016/S0006-3223(98)00135-8

DO - 10.1016/S0006-3223(98)00135-8

M3 - Article

SN - 0006-3223

VL - 45

SP - 652

EP - 654

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 5

ER -

DAT1 Gene Polymorphism in Alcoholism: A Family-Based Association Study

Abstract

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