Dairy Intake and Body Composition and Cardiometabolic Traits among Adults: Mendelian Randomization Analysis of 182041 Individuals from 18 Studies

Mendelian Randomization Dairy Cons, CHARGE consortium

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND: Associations between dairy intake and body composition and cardiometabolic traits have been inconsistently observed in epidemiological studies, and the causal relationship remains ill-defined.

METHODS: We performed Mendelian randomization analysis using an established genetic variant located upstream of the lactase gene (LCT- 13910 C/T, rs4988235) associated with dairy intake as an instrumental variable (IV). The causal effects of dairy intake on body composition and cardiometabolic traits (lipids, glycemic traits, and inflammatory factors) were quantified by IV estimators among 182041 participants from 18 studies.

RESULTS: Each 1 serving/day higher dairy intake was associated with higher lean mass [beta (SE) = 0.117 kg (0.035); P = 0.001], higher hemoglobin A(1c) [0.009% (0.002); P <0.001], lower LDL [-0.014 mmol/L (0.006); P = 0.013], total cholesterol (TC) [-0.012 mmol/L (0.005); P = 0.023], and non-HDL [- 0.012 mmol/L (0.005); P = 0.028]. The LCT- 13910 C/T CT + TT genotype was associated with 0.214 more dairy servings/day (SE = 0.047; P = 0.001), 0.284 cm higher waist circumference (SE = 0.118; P = 0.017), 0.112 kg higher lean mass (SE = 0.027; P = 3.8 X 10(-5)), 0.032 mmol/L lower LDL (SE = 0.009; P = 0.001), and 0.032 mmol/L lower TC (SE = 0.010; P = 0.001). Genetically higher dairy intake was associated with increased lean mass [0.523 kg per serving/day (0.170); P = 0.002] after correction for multiple testing (0.05/18). However, we find that genetically higher dairy intake was not associated with lipids and glycemic traits.

CONCLUSIONS: The present study provides evidence to support a potential causal effect of higher dairy intake on increased lean mass among adults. Our findings suggest that the observational associations of dairy intake with lipids and glycemic traits may be the result of confounding. (C) 2019 American Association for Clinical Chemistry

Original languageEnglish
Pages (from-to)751-760
Number of pages10
JournalClinical Chemistry
Volume65
Issue number6
DOIs
Publication statusPublished - Jun 2019

Cite this

@article{92dd93ab4765464baf3e1e4072d05034,
title = "Dairy Intake and Body Composition and Cardiometabolic Traits among Adults: Mendelian Randomization Analysis of 182041 Individuals from 18 Studies",
abstract = "BACKGROUND: Associations between dairy intake and body composition and cardiometabolic traits have been inconsistently observed in epidemiological studies, and the causal relationship remains ill-defined.METHODS: We performed Mendelian randomization analysis using an established genetic variant located upstream of the lactase gene (LCT- 13910 C/T, rs4988235) associated with dairy intake as an instrumental variable (IV). The causal effects of dairy intake on body composition and cardiometabolic traits (lipids, glycemic traits, and inflammatory factors) were quantified by IV estimators among 182041 participants from 18 studies.RESULTS: Each 1 serving/day higher dairy intake was associated with higher lean mass [beta (SE) = 0.117 kg (0.035); P = 0.001], higher hemoglobin A(1c) [0.009{\%} (0.002); P <0.001], lower LDL [-0.014 mmol/L (0.006); P = 0.013], total cholesterol (TC) [-0.012 mmol/L (0.005); P = 0.023], and non-HDL [- 0.012 mmol/L (0.005); P = 0.028]. The LCT- 13910 C/T CT + TT genotype was associated with 0.214 more dairy servings/day (SE = 0.047; P = 0.001), 0.284 cm higher waist circumference (SE = 0.118; P = 0.017), 0.112 kg higher lean mass (SE = 0.027; P = 3.8 X 10(-5)), 0.032 mmol/L lower LDL (SE = 0.009; P = 0.001), and 0.032 mmol/L lower TC (SE = 0.010; P = 0.001). Genetically higher dairy intake was associated with increased lean mass [0.523 kg per serving/day (0.170); P = 0.002] after correction for multiple testing (0.05/18). However, we find that genetically higher dairy intake was not associated with lipids and glycemic traits.CONCLUSIONS: The present study provides evidence to support a potential causal effect of higher dairy intake on increased lean mass among adults. Our findings suggest that the observational associations of dairy intake with lipids and glycemic traits may be the result of confounding. (C) 2019 American Association for Clinical Chemistry",
keywords = "MILK INTAKE, DIETARY CALCIUM, LACTASE GENE, WEIGHT-GAIN, RISK, METAANALYSIS, CONSUMPTION, PRODUCT, HETEROGENEITY, OVERWEIGHT",
author = "{Mendelian Randomization Dairy Cons} and {CHARGE consortium} and Tao Huang and Dianjianyi Sun and Yoriko Heianza and Bergholdt, {Helle K. M.} and Meng Gao and Zhe Fang and Ming Ding and Frazier-Wood, {Alexis C.} and North, {Kari E.} and Eirini Marouli and Mariaelisa Graff and Smith, {Caren E.} and Anette Varbo and Lemaitre, {Rozenn N.} and Dolores Corella and Wang, {Carol A.} and Anne Tjonneland and Kim Overvad and Sorensen, {Thorkild I. A.} and Feitosa, {Mary F.} and Wojczynski, {Mary K.} and Mika Kahonen and Vera Mikkila and Bartz, {Traci M.} and Psaty, {Bruce M.} and Siscovick, {David S.} and Danning, {Rebecca D.} and George Dedoussis and Oluf Pedersen and Torben Hansen and Havulinna, {Aki S.} and Satu Mannisto and Jerome Rotter and Laura Sares-Jaske and Allison, {Mathew A.} and Rich, {Stephen S.} and Jose Sorli and Oscar Coltell and Pennell, {Craig E.} and Peter Eastwood and Ridker, {Paul M.} and Jorma Viikari and Olli Raitakari and Terho Lehtimaki and Mika Helminen and Yujie Wang and Panagiotis Deloukas and Paul Knekt and Noora Kanerva and Kilpelainen, {Tuomas O.} and Province, {Michael A.} and Dariush Mozaffarian and Daniel Chasman and Nordestgaard, {Borge G.} and Christina Ellervik and Lu Qi",
year = "2019",
month = "6",
doi = "10.1373/clinchem.2018.300335",
language = "English",
volume = "65",
pages = "751--760",
journal = "Clinical Chemistry",
issn = "0009-9147",
publisher = "AMER ASSOC CLINICAL CHEMISTRY",
number = "6",

}

Dairy Intake and Body Composition and Cardiometabolic Traits among Adults : Mendelian Randomization Analysis of 182041 Individuals from 18 Studies. / Mendelian Randomization Dairy Cons; CHARGE consortium.

In: Clinical Chemistry, Vol. 65, No. 6, 06.2019, p. 751-760.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dairy Intake and Body Composition and Cardiometabolic Traits among Adults

T2 - Mendelian Randomization Analysis of 182041 Individuals from 18 Studies

AU - Mendelian Randomization Dairy Cons

AU - CHARGE consortium

AU - Huang, Tao

AU - Sun, Dianjianyi

AU - Heianza, Yoriko

AU - Bergholdt, Helle K. M.

AU - Gao, Meng

AU - Fang, Zhe

AU - Ding, Ming

AU - Frazier-Wood, Alexis C.

AU - North, Kari E.

AU - Marouli, Eirini

AU - Graff, Mariaelisa

AU - Smith, Caren E.

AU - Varbo, Anette

AU - Lemaitre, Rozenn N.

AU - Corella, Dolores

AU - Wang, Carol A.

AU - Tjonneland, Anne

AU - Overvad, Kim

AU - Sorensen, Thorkild I. A.

AU - Feitosa, Mary F.

AU - Wojczynski, Mary K.

AU - Kahonen, Mika

AU - Mikkila, Vera

AU - Bartz, Traci M.

AU - Psaty, Bruce M.

AU - Siscovick, David S.

AU - Danning, Rebecca D.

AU - Dedoussis, George

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Havulinna, Aki S.

AU - Mannisto, Satu

AU - Rotter, Jerome

AU - Sares-Jaske, Laura

AU - Allison, Mathew A.

AU - Rich, Stephen S.

AU - Sorli, Jose

AU - Coltell, Oscar

AU - Pennell, Craig E.

AU - Eastwood, Peter

AU - Ridker, Paul M.

AU - Viikari, Jorma

AU - Raitakari, Olli

AU - Lehtimaki, Terho

AU - Helminen, Mika

AU - Wang, Yujie

AU - Deloukas, Panagiotis

AU - Knekt, Paul

AU - Kanerva, Noora

AU - Kilpelainen, Tuomas O.

AU - Province, Michael A.

AU - Mozaffarian, Dariush

AU - Chasman, Daniel

AU - Nordestgaard, Borge G.

AU - Ellervik, Christina

AU - Qi, Lu

PY - 2019/6

Y1 - 2019/6

N2 - BACKGROUND: Associations between dairy intake and body composition and cardiometabolic traits have been inconsistently observed in epidemiological studies, and the causal relationship remains ill-defined.METHODS: We performed Mendelian randomization analysis using an established genetic variant located upstream of the lactase gene (LCT- 13910 C/T, rs4988235) associated with dairy intake as an instrumental variable (IV). The causal effects of dairy intake on body composition and cardiometabolic traits (lipids, glycemic traits, and inflammatory factors) were quantified by IV estimators among 182041 participants from 18 studies.RESULTS: Each 1 serving/day higher dairy intake was associated with higher lean mass [beta (SE) = 0.117 kg (0.035); P = 0.001], higher hemoglobin A(1c) [0.009% (0.002); P <0.001], lower LDL [-0.014 mmol/L (0.006); P = 0.013], total cholesterol (TC) [-0.012 mmol/L (0.005); P = 0.023], and non-HDL [- 0.012 mmol/L (0.005); P = 0.028]. The LCT- 13910 C/T CT + TT genotype was associated with 0.214 more dairy servings/day (SE = 0.047; P = 0.001), 0.284 cm higher waist circumference (SE = 0.118; P = 0.017), 0.112 kg higher lean mass (SE = 0.027; P = 3.8 X 10(-5)), 0.032 mmol/L lower LDL (SE = 0.009; P = 0.001), and 0.032 mmol/L lower TC (SE = 0.010; P = 0.001). Genetically higher dairy intake was associated with increased lean mass [0.523 kg per serving/day (0.170); P = 0.002] after correction for multiple testing (0.05/18). However, we find that genetically higher dairy intake was not associated with lipids and glycemic traits.CONCLUSIONS: The present study provides evidence to support a potential causal effect of higher dairy intake on increased lean mass among adults. Our findings suggest that the observational associations of dairy intake with lipids and glycemic traits may be the result of confounding. (C) 2019 American Association for Clinical Chemistry

AB - BACKGROUND: Associations between dairy intake and body composition and cardiometabolic traits have been inconsistently observed in epidemiological studies, and the causal relationship remains ill-defined.METHODS: We performed Mendelian randomization analysis using an established genetic variant located upstream of the lactase gene (LCT- 13910 C/T, rs4988235) associated with dairy intake as an instrumental variable (IV). The causal effects of dairy intake on body composition and cardiometabolic traits (lipids, glycemic traits, and inflammatory factors) were quantified by IV estimators among 182041 participants from 18 studies.RESULTS: Each 1 serving/day higher dairy intake was associated with higher lean mass [beta (SE) = 0.117 kg (0.035); P = 0.001], higher hemoglobin A(1c) [0.009% (0.002); P <0.001], lower LDL [-0.014 mmol/L (0.006); P = 0.013], total cholesterol (TC) [-0.012 mmol/L (0.005); P = 0.023], and non-HDL [- 0.012 mmol/L (0.005); P = 0.028]. The LCT- 13910 C/T CT + TT genotype was associated with 0.214 more dairy servings/day (SE = 0.047; P = 0.001), 0.284 cm higher waist circumference (SE = 0.118; P = 0.017), 0.112 kg higher lean mass (SE = 0.027; P = 3.8 X 10(-5)), 0.032 mmol/L lower LDL (SE = 0.009; P = 0.001), and 0.032 mmol/L lower TC (SE = 0.010; P = 0.001). Genetically higher dairy intake was associated with increased lean mass [0.523 kg per serving/day (0.170); P = 0.002] after correction for multiple testing (0.05/18). However, we find that genetically higher dairy intake was not associated with lipids and glycemic traits.CONCLUSIONS: The present study provides evidence to support a potential causal effect of higher dairy intake on increased lean mass among adults. Our findings suggest that the observational associations of dairy intake with lipids and glycemic traits may be the result of confounding. (C) 2019 American Association for Clinical Chemistry

KW - MILK INTAKE

KW - DIETARY CALCIUM

KW - LACTASE GENE

KW - WEIGHT-GAIN

KW - RISK

KW - METAANALYSIS

KW - CONSUMPTION

KW - PRODUCT

KW - HETEROGENEITY

KW - OVERWEIGHT

U2 - 10.1373/clinchem.2018.300335

DO - 10.1373/clinchem.2018.300335

M3 - Article

VL - 65

SP - 751

EP - 760

JO - Clinical Chemistry

JF - Clinical Chemistry

SN - 0009-9147

IS - 6

ER -