Projects per year
OBJECTIVE To examine whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal.
Mendelian randomization study using the single nucleotide polymorphism rs4988235 related to lactase persistence as an instrumental variable.
CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium.
Data from 22 studies with 171 213 participants, and an additional 10 published prospective studies with 26 119 participants included in the observational analysis.
MAIN OUTCOME MEASURES
The instrumental variable estimation was conducted using the ratio of coefficients approach. Using metaanalysis, an additional eight published randomized clinical trials on the association of dairy consumption with systolic blood pressure were summarized.
Compared with the CC genotype (CC is associated with complete lactase deficiency), the CT/TT genotype (TT is associated with lactose persistence, and CT is associated with certain lactase deficiency) of LCT-13910 (lactase persistence gene) rs4988235 was associated with higher dairy consumption (0.23 (about 55 g/day), 95% confidence interval 0.17 to 0.29) serving/day; P
The weak inverse association between dairy intake and systolic blood pressure in observational studies was not supported by a comprehensive instrumental variable analysis and systematic review of existing clinical trials.
|Number of pages||10|
|Journal||British Medical Journal Open Access (Online )|
|Publication status||Published - 16 Mar 2017|
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- 2 Finished
Childhood Obesity & its Relationship to Adult Sleep Disordered Breathing
Eastwood, P., Hillman, D., Smith, A., McArdle, N. & Huang, R.
National Health & Medical Research Council NHMRC
1/01/12 → 31/12/14
403981: Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 Year Follow up of a Longitudinal Cohort
Beilin, L., Palmer, L., Oddy, W., Mori, T., Kendall, G. & Hands, B.
1/01/06 → 31/12/09