TY - JOUR
T1 - Cytotoxic prenylated flavones from Artocarpus champeden
AU - Syah, Y.M.
AU - Juliawaty, L.D.
AU - Achmad, S.A.
AU - Hakim, E.H.
AU - Ghisalberti, Emilio
PY - 2006
Y1 - 2006
N2 - Two new prenylated flavones, artoindonesianins A-2 (1) and A-3 (2), together with three known prenylated flavones, artonin B (3), heterophyllin (4) and cudraflavone C (5), have been isolated and identified from the chloroform extract of the heartwood of Artocarpus champeden. The structures of these compounds were determined on the basis of spectroscopic data, including UV, IR, 1-D and 2-D NMR, and mass spectra. The cytotoxic properties of the new compounds, together with three prenylated flavones isolated previously, artoindonesianins Q (6), R (7) and T (8), were evaluated against murine leukemia P-388 cells. Based on their IC50 values, compounds 1, 2, 4, 5 and 8 showed strong cytotoxic properties.
AB - Two new prenylated flavones, artoindonesianins A-2 (1) and A-3 (2), together with three known prenylated flavones, artonin B (3), heterophyllin (4) and cudraflavone C (5), have been isolated and identified from the chloroform extract of the heartwood of Artocarpus champeden. The structures of these compounds were determined on the basis of spectroscopic data, including UV, IR, 1-D and 2-D NMR, and mass spectra. The cytotoxic properties of the new compounds, together with three prenylated flavones isolated previously, artoindonesianins Q (6), R (7) and T (8), were evaluated against murine leukemia P-388 cells. Based on their IC50 values, compounds 1, 2, 4, 5 and 8 showed strong cytotoxic properties.
U2 - 10.1007/s11418-006-0012-z
DO - 10.1007/s11418-006-0012-z
M3 - Article
VL - 60
SP - 308
EP - 312
JO - Journal of Natural Medicines
JF - Journal of Natural Medicines
SN - 1340-3443
ER -