Cytotoxic prenylated flavones from Artocarpus champeden

Y.M. Syah, L.D. Juliawaty, S.A. Achmad, E.H. Hakim, Emilio Ghisalberti

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Two new prenylated flavones, artoindonesianins A-2 (1) and A-3 (2), together with three known prenylated flavones, artonin B (3), heterophyllin (4) and cudraflavone C (5), have been isolated and identified from the chloroform extract of the heartwood of Artocarpus champeden. The structures of these compounds were determined on the basis of spectroscopic data, including UV, IR, 1-D and 2-D NMR, and mass spectra. The cytotoxic properties of the new compounds, together with three prenylated flavones isolated previously, artoindonesianins Q (6), R (7) and T (8), were evaluated against murine leukemia P-388 cells. Based on their IC50 values, compounds 1, 2, 4, 5 and 8 showed strong cytotoxic properties.
Original languageEnglish
Pages (from-to)308-312
JournalJournal of Natural Medicines
Volume60
DOIs
Publication statusPublished - 2006

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