Cytosine-gated hole creation and transfer in DNA in aqueous solution

Robert F. Anderson; Sujata S. Shinde; Andrej Maroz

doi:10.1021/ja0658416

Cytosine-gated hole creation and transfer in DNA in aqueous solution

Robert F. Anderson, Sujata S. Shinde, Andrej Maroz

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

The selenite radical, SeO₃^-, has been found to selectively produce the cytosyl radical upon one-electron oxidation of duplex DNA. This is at first a surprising result as SeO₃^- can only oxidize guanine of the DNA bases, implying that the transiently formed guanyl radical cation must transpose into the neutral cytosyl radical with loss of a proton. Back oxidation to produce the neutral guanyl radical, in competition with another fixation reaction, is observed.

Original language	English
Pages (from-to)	15966-15967
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	50
DOIs	https://doi.org/10.1021/ja0658416
Publication status	Published - 20 Dec 2006
Externally published	Yes

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abstract = "The selenite radical, SeO3-, has been found to selectively produce the cytosyl radical upon one-electron oxidation of duplex DNA. This is at first a surprising result as SeO3- can only oxidize guanine of the DNA bases, implying that the transiently formed guanyl radical cation must transpose into the neutral cytosyl radical with loss of a proton. Back oxidation to produce the neutral guanyl radical, in competition with another fixation reaction, is observed.",

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AB - The selenite radical, SeO3-, has been found to selectively produce the cytosyl radical upon one-electron oxidation of duplex DNA. This is at first a surprising result as SeO3- can only oxidize guanine of the DNA bases, implying that the transiently formed guanyl radical cation must transpose into the neutral cytosyl radical with loss of a proton. Back oxidation to produce the neutral guanyl radical, in competition with another fixation reaction, is observed.

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Cytosine-gated hole creation and transfer in DNA in aqueous solution

Abstract

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