Abstract
Evidence suggests latent cytomegalovirus (CMV) infection may increase risk of chronic disease in HIV-infected persons on anti-retroviral therapy (ART). This work explored CMV-specific antibodies (IE-1, gB and lysate ant1gens) as a biomarker for cardiovascular disease, neurocognitive impairment or insulin resistance in Australian HIV cohorts. Levels of autoantibody, total antibody and inflammatory markers were characterised in longitudinal and cross-sectional studies. A novel association between cytomegalovirus antibody and insulin resistance was found, independent of CD4 T-cell depletion, total antibody level and ageing. The findings suggest elevated CMV antibody levels may be indicative of developing insulin resistance in HIV patients on ART.
| Original language | English |
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| Qualification | Masters |
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| Award date | 16 Aug 2016 |
| Publication status | Unpublished - 2016 |
Access to Document
- THESIS - MASTER BY RESEARCH - BRUNT Samantha Jane - 2016
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