Cytomegalovirus antibody and vascular pathology in renal transplant recipients

Patricia Price, Silvia Lee, Jacquita Affandi, Richard Parsons, Louise H. Naylor, Gerald F. Watts, Ashley Irish

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    Abstract

    Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients than healthy controls (P < 0.001), and correlated with vascular endothelial function measured by flow mediated-dilation of the brachial artery (FMD). However, the optimal general linear model predicting FMD included CMV seropositivity as a marginal effect (P = 0.068), with age (P = 0.013), gender (P < 0.0001), and transplantation (P < 0.0001). Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease. J. Med. Virol. 89:177–181, 2017.

    Original languageEnglish
    Pages (from-to)177-181
    Number of pages5
    JournalJournal of Medical Virology
    Volume89
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2017

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