Cytomegalovirus antibody and vascular pathology in renal transplant recipients

Patricia Price, Silvia Lee, Jacquita Affandi, Richard Parsons, Louise H. Naylor, Gerald F. Watts, Ashley Irish

    Research output: Contribution to journalArticle

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    Abstract

    Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients than healthy controls (P < 0.001), and correlated with vascular endothelial function measured by flow mediated-dilation of the brachial artery (FMD). However, the optimal general linear model predicting FMD included CMV seropositivity as a marginal effect (P = 0.068), with age (P = 0.013), gender (P < 0.0001), and transplantation (P < 0.0001). Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease. J. Med. Virol. 89:177–181, 2017.

    Original languageEnglish
    Pages (from-to)177-181
    Number of pages5
    JournalJournal of Medical Virology
    Volume89
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2017

    Fingerprint

    Cytomegalovirus
    Blood Vessels
    Pathology
    Kidney
    Antibodies
    Brachial Artery
    Vascular Diseases
    Kidney Transplantation
    Transplant Recipients
    Dilatation
    Linear Models
    Transplantation
    Transplants

    Cite this

    Price, Patricia ; Lee, Silvia ; Affandi, Jacquita ; Parsons, Richard ; Naylor, Louise H. ; Watts, Gerald F. ; Irish, Ashley. / Cytomegalovirus antibody and vascular pathology in renal transplant recipients. In: Journal of Medical Virology. 2017 ; Vol. 89, No. 1. pp. 177-181.
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    abstract = "Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients than healthy controls (P < 0.001), and correlated with vascular endothelial function measured by flow mediated-dilation of the brachial artery (FMD). However, the optimal general linear model predicting FMD included CMV seropositivity as a marginal effect (P = 0.068), with age (P = 0.013), gender (P < 0.0001), and transplantation (P < 0.0001). Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease. J. Med. Virol. 89:177–181, 2017.",
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    Cytomegalovirus antibody and vascular pathology in renal transplant recipients. / Price, Patricia; Lee, Silvia; Affandi, Jacquita; Parsons, Richard; Naylor, Louise H.; Watts, Gerald F.; Irish, Ashley.

    In: Journal of Medical Virology, Vol. 89, No. 1, 01.01.2017, p. 177-181.

    Research output: Contribution to journalArticle

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    T1 - Cytomegalovirus antibody and vascular pathology in renal transplant recipients

    AU - Price, Patricia

    AU - Lee, Silvia

    AU - Affandi, Jacquita

    AU - Parsons, Richard

    AU - Naylor, Louise H.

    AU - Watts, Gerald F.

    AU - Irish, Ashley

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    AB - Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients than healthy controls (P < 0.001), and correlated with vascular endothelial function measured by flow mediated-dilation of the brachial artery (FMD). However, the optimal general linear model predicting FMD included CMV seropositivity as a marginal effect (P = 0.068), with age (P = 0.013), gender (P < 0.0001), and transplantation (P < 0.0001). Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease. J. Med. Virol. 89:177–181, 2017.

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