Cytokine-induced coordinate expression of enzymes of prostaglandin biosynthesis and metabolism: 15-hydroxyprostaglandin dehydrogenase

MD Mitchell, V Goodwin, S Mesnage, Jeffrey Keelan

    Research output: Contribution to journalArticle

    35 Citations (Scopus)

    Abstract

    The effects of pro-inflammatory cytokines on 15-hydroxyprostaglandin dehydrogenase (PGDH) expression and prostaglandin (PG) metabolizing activity were investigated in placental tissue. Treatment of trophoblast cells in primary culture with interleukin-1 beta (IL-1 beta) or tumour necrosis factor-alpha (TNF-alpha) resulted in decreased prostaglandin metabolizing activity. This was assessed both by determining the ratio of production of prostaglandins to their metabolites, and by Northern blot analysis of PGDH mRNA abundance. Dexamethasone had similar inhibitory effect. We hypothesize that proinflammatory cytokines act to enhance prostaglandin actions through coordinated effects on activities of enzymes of both prostaglandin biosynthesis and metabolism, perhaps in concert with effects on receptor function. (C) 2000 Harcourt Publishers Ltd.
    Original languageEnglish
    Pages (from-to)1-5
    JournalProstaglandins, Leukotrienes and Essential Fatty Acids
    Volume62
    DOIs
    Publication statusPublished - 2000

    Fingerprint Dive into the research topics of 'Cytokine-induced coordinate expression of enzymes of prostaglandin biosynthesis and metabolism: 15-hydroxyprostaglandin dehydrogenase'. Together they form a unique fingerprint.

    Cite this