Cyclin D1 functions in cell migration

Zhiping Li; Chenguang Wang; George C. Prendergast; Richard G. Pestell

doi:10.4161/cc.5.21.3428

Cyclin D1 functions in cell migration

Zhiping Li, Chenguang Wang, George C. Prendergast, Richard G. Pestell

Research output: Contribution to journal › Short survey › peer-review

105 Citations (Scopus)

Abstract

Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer. Given the frequent overexpression of cyclin D1 in cancer cells, due to its upregulation by Ras, Rho, Src, and other genes that drive malignant development, the new findings suggest that cyclin D1 may have a central role in mediating invasion and metastasis of cancer cells by controlling Rho/ROCK signaling and matrix deposition of TSP-1.

Original language	English
Pages (from-to)	2440-2442
Number of pages	3
Journal	Cell Cycle
Volume	5
Issue number	21
DOIs	https://doi.org/10.4161/cc.5.21.3428
Publication status	Published - 1 Nov 2006
Externally published	Yes

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title = "Cyclin D1 functions in cell migration",

abstract = "Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer. Given the frequent overexpression of cyclin D1 in cancer cells, due to its upregulation by Ras, Rho, Src, and other genes that drive malignant development, the new findings suggest that cyclin D1 may have a central role in mediating invasion and metastasis of cancer cells by controlling Rho/ROCK signaling and matrix deposition of TSP-1.",

keywords = "Cyclin D1, Migration, Rho, ROCK, TSP-1",

author = "Zhiping Li and Chenguang Wang and Prendergast, {George C.} and Pestell, {Richard G.}",

year = "2006",

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doi = "10.4161/cc.5.21.3428",

language = "English",

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journal = "Cell Cycle",

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T1 - Cyclin D1 functions in cell migration

AU - Li, Zhiping

AU - Wang, Chenguang

AU - Prendergast, George C.

AU - Pestell, Richard G.

PY - 2006/11/1

Y1 - 2006/11/1

N2 - Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer. Given the frequent overexpression of cyclin D1 in cancer cells, due to its upregulation by Ras, Rho, Src, and other genes that drive malignant development, the new findings suggest that cyclin D1 may have a central role in mediating invasion and metastasis of cancer cells by controlling Rho/ROCK signaling and matrix deposition of TSP-1.

AB - Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer. Given the frequent overexpression of cyclin D1 in cancer cells, due to its upregulation by Ras, Rho, Src, and other genes that drive malignant development, the new findings suggest that cyclin D1 may have a central role in mediating invasion and metastasis of cancer cells by controlling Rho/ROCK signaling and matrix deposition of TSP-1.

KW - Cyclin D1

KW - Migration

KW - Rho

KW - ROCK

KW - TSP-1

UR - http://www.scopus.com/inward/record.url?scp=33751250793&partnerID=8YFLogxK

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DO - 10.4161/cc.5.21.3428

M3 - Short survey

C2 - 17106256

AN - SCOPUS:33751250793

SN - 1538-4101

VL - 5

SP - 2440

EP - 2442

JO - Cell Cycle

JF - Cell Cycle

IS - 21

ER -

Cyclin D1 functions in cell migration

Abstract

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