TY - JOUR
T1 - Cutting edge: a NK complex-linked locus governs acute versus latent herpes simplex virus infection of neurons
AU - Pereira, R.A.
AU - Scalzo, Tony
AU - Simmons, A.
PY - 2001
Y1 - 2001
N2 - Herpes simplex causes latent infections that periodically reactivate. Specific immunization attempts are failing to control herpes, prompting a fresh look at which host responses predominate. We report a NK complex-linked genetic locus, Rhs1, whose alleles influence the magnitude of experimental herpes simplex. Rhs1 provided rapid control of primary infection but caused a reciprocal increase In the number of latently infected neurons. Thus, in principle, establishment of latency is a consequence of efficient front line defense against herpesvirus infection. Based on conservation between human and mouse NK complexes, the data predict the presence of a human Rhs1 orthologue on chromosome 12p12-13.
AB - Herpes simplex causes latent infections that periodically reactivate. Specific immunization attempts are failing to control herpes, prompting a fresh look at which host responses predominate. We report a NK complex-linked genetic locus, Rhs1, whose alleles influence the magnitude of experimental herpes simplex. Rhs1 provided rapid control of primary infection but caused a reciprocal increase In the number of latently infected neurons. Thus, in principle, establishment of latency is a consequence of efficient front line defense against herpesvirus infection. Based on conservation between human and mouse NK complexes, the data predict the presence of a human Rhs1 orthologue on chromosome 12p12-13.
U2 - 10.4049/jimmunol.166.10.5869
DO - 10.4049/jimmunol.166.10.5869
M3 - Article
SN - 0022-1767
VL - 166
SP - 5869
EP - 5873
JO - Journal of Immunology
JF - Journal of Immunology
ER -