Cutting edge: a NK complex-linked locus governs acute versus latent herpes simplex virus infection of neurons

R.A. Pereira, Tony Scalzo, A. Simmons

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Herpes simplex causes latent infections that periodically reactivate. Specific immunization attempts are failing to control herpes, prompting a fresh look at which host responses predominate. We report a NK complex-linked genetic locus, Rhs1, whose alleles influence the magnitude of experimental herpes simplex. Rhs1 provided rapid control of primary infection but caused a reciprocal increase In the number of latently infected neurons. Thus, in principle, establishment of latency is a consequence of efficient front line defense against herpesvirus infection. Based on conservation between human and mouse NK complexes, the data predict the presence of a human Rhs1 orthologue on chromosome 12p12-13.
Original languageEnglish
Pages (from-to)5869-5873
JournalJournal of Immunology
Volume166
DOIs
Publication statusPublished - 2001

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