Cuticular drusen in an Indigenous Australian

William J. Cunningham, Chandrakumar Balaratnasingam, Yi Chen, Fred K Chen

Research output: Contribution to journalArticlepeer-review


BACKGROUND/PURPOSE: To report a case of cuticular drusen in an indigenous Australian.

METHODS: A 37-year-old indigenous (aboriginal) Australian woman from a remote Western Australian town presented with a 2-month history of vision loss. Clinical history, examination, and multimodal retinal imaging data from spectral domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, and indocyanine green angiography were analyzed.

RESULTS: Multimodal imaging confirmed cuticular drusen complicated by a right choroidal neovascularization with pigment epithelial detachment and a left foveal vitelliform lesion. An unusual "negative-staining" pattern was noted on late phase indocyanine green angiography and this spared the regions affected by cuticular drusen.

CONCLUSION: To the best of our knowledge, this is the first published report of cuticular drusen in an indigenous Australian. We hypothesize that this may be secondary to ancestral mixing of the gene pool. An unusual staining pattern witnessed on indocyanine green angiography suggests widespread disturbance of lipoprotein deposition in the Bruch membrane.

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalRetinal Cases and Brief Reports
Issue number3
Early online date5 Dec 2017
Publication statusPublished - 1 Jun 2020


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