Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition

Nathan Harvey, Michael Millward, K. Macgregor, R.P. Bucat, Benjamin Wood

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. With increasing use of immune-modulating drugs, this potential histological mimic may be seen more frequently in the future.
    Original languageEnglish
    Pages (from-to)e159-e162
    JournalAmerican Journal of Dermatopathology
    Volume38
    Issue number12
    DOIs
    Publication statusPublished - 2016

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    Halo Nevi
    Melanoma
    Antibodies, Monoclonal, Humanized
    Skin
    Neoplasm Metastasis
    Health
    Pharmaceutical Preparations
    Therapeutics

    Cite this

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    title = "Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition",
    abstract = "{\circledC} Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. With increasing use of immune-modulating drugs, this potential histological mimic may be seen more frequently in the future.",
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    Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition. / Harvey, Nathan; Millward, Michael; Macgregor, K.; Bucat, R.P.; Wood, Benjamin.

    In: American Journal of Dermatopathology, Vol. 38, No. 12, 2016, p. e159-e162.

    Research output: Contribution to journalArticle

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    T1 - Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition

    AU - Harvey, Nathan

    AU - Millward, Michael

    AU - Macgregor, K.

    AU - Bucat, R.P.

    AU - Wood, Benjamin

    PY - 2016

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    N2 - © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. With increasing use of immune-modulating drugs, this potential histological mimic may be seen more frequently in the future.

    AB - © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. With increasing use of immune-modulating drugs, this potential histological mimic may be seen more frequently in the future.

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    JF - The American Journal of dermatopathology

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