Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition

Nathan Harvey; Michael Millward; K. Macgregor; R.P. Bucat; Benjamin Wood

doi:10.1097/DAD.0000000000000668

Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition

Nathan Harvey, Michael Millward, K. Macgregor, R.P. Bucat, Benjamin Wood

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

© Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. With increasing use of immune-modulating drugs, this potential histological mimic may be seen more frequently in the future.

Original language	English
Pages (from-to)	e159-e162
Journal	American Journal of Dermatopathology
Volume	38
Issue number	12
DOIs	https://doi.org/10.1097/DAD.0000000000000668
Publication status	Published - 2016

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abstract = "{\textcopyright} Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. With increasing use of immune-modulating drugs, this potential histological mimic may be seen more frequently in the future.",

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T1 - Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition

AU - Harvey, Nathan

AU - Millward, Michael

AU - Macgregor, K.

AU - Bucat, R.P.

AU - Wood, Benjamin

PY - 2016

Y1 - 2016

N2 - © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. With increasing use of immune-modulating drugs, this potential histological mimic may be seen more frequently in the future.

AB - © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. With increasing use of immune-modulating drugs, this potential histological mimic may be seen more frequently in the future.

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DO - 10.1097/DAD.0000000000000668

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JO - The American Journal of dermatopathology

JF - The American Journal of dermatopathology

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