Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition

Nathan Harvey, Michael Millward, K. Macgregor, R.P. Bucat, Benjamin Wood

    Research output: Contribution to journal › Article

    3 Citations (Scopus)

    Abstract

    © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. With increasing use of immune-modulating drugs, this potential histological mimic may be seen more frequently in the future.
    Original languageEnglish
    Pages (from-to)e159-e162
    JournalAmerican Journal of Dermatopathology
    Volume38
    Issue number12
    DOIs
    Publication statusPublished - 2016

    Fingerprint

    Halo Nevi
    Melanoma
    Antibodies, Monoclonal, Humanized
    Skin
    Neoplasm Metastasis
    Health
    Pharmaceutical Preparations
    Therapeutics

    Cite this

    Harvey, Nathan ; Millward, Michael ; Macgregor, K. ; Bucat, R.P. ; Wood, Benjamin. / Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition. In: American Journal of Dermatopathology. 2016 ; Vol. 38, No. 12. pp. e159-e162.
    @article{bb472e865d504eb6884d952d2f5680e8,
    title = "Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition",
    abstract = "{\circledC} Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. With increasing use of immune-modulating drugs, this potential histological mimic may be seen more frequently in the future.",
    author = "Nathan Harvey and Michael Millward and K. Macgregor and R.P. Bucat and Benjamin Wood",
    year = "2016",
    doi = "10.1097/DAD.0000000000000668",
    language = "English",
    volume = "38",
    pages = "e159--e162",
    journal = "The American Journal of dermatopathology",
    issn = "0193-1091",
    publisher = "Lippincott Williams & Wilkins",
    number = "12",

    }

    Harvey, N, Millward, M, Macgregor, K, Bucat, RP & Wood, B 2016, 'Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition' American Journal of Dermatopathology, vol. 38, no. 12, pp. e159-e162. https://doi.org/10.1097/DAD.0000000000000668

    Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition. / Harvey, Nathan; Millward, Michael; Macgregor, K.; Bucat, R.P.; Wood, Benjamin.

    In: American Journal of Dermatopathology, Vol. 38, No. 12, 2016, p. e159-e162.

    Research output: Contribution to journal › Article

    TY - JOUR

    T1 - Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition

    AU - Harvey, Nathan

    AU - Millward, Michael

    AU - Macgregor, K.

    AU - Bucat, R.P.

    AU - Wood, Benjamin

    PY - 2016

    Y1 - 2016

    N2 - © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. With increasing use of immune-modulating drugs, this potential histological mimic may be seen more frequently in the future.

    AB - © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. With increasing use of immune-modulating drugs, this potential histological mimic may be seen more frequently in the future.

    U2 - 10.1097/DAD.0000000000000668

    DO - 10.1097/DAD.0000000000000668

    M3 - Article

    VL - 38

    SP - e159-e162

    JO - The American Journal of dermatopathology

    JF - The American Journal of dermatopathology

    SN - 0193-1091

    IS - 12

    ER -

    Harvey N, Millward M, Macgregor K, Bucat RP, Wood B. Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition. American Journal of Dermatopathology. 2016;38(12):e159-e162. https://doi.org/10.1097/DAD.0000000000000668

    Access to Document