Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis

Andrzej T. Slominski, Anna A. Brożyna, Robert C. Tuckey

Research output: Contribution to journalComment/debate

6 Citations (Scopus)

Abstract

Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.

Original languageEnglish
Pages (from-to)1609-1611
Number of pages3
JournalJournal of Investigative Dermatology
Volume137
Issue number8
DOIs
Publication statusPublished - 1 Aug 2017

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Psoriasis
Glucocorticoids
Hydrocortisone
Pro-Opiomelanocortin
Skin
Glucocorticoid Receptors
Restoration
Feedback
Skin Diseases
Immunity

Cite this

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title = "Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis",
abstract = "Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.",
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Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis. / Slominski, Andrzej T.; Brożyna, Anna A.; Tuckey, Robert C.

In: Journal of Investigative Dermatology, Vol. 137, No. 8, 01.08.2017, p. 1609-1611.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis

AU - Slominski, Andrzej T.

AU - Brożyna, Anna A.

AU - Tuckey, Robert C.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.

AB - Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.

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U2 - 10.1016/j.jid.2017.04.004

DO - 10.1016/j.jid.2017.04.004

M3 - Comment/debate

VL - 137

SP - 1609

EP - 1611

JO - The Journal of Investigative Dermatology

JF - The Journal of Investigative Dermatology

SN - 0022-202X

IS - 8

ER -