Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis

Andrzej T. Slominski; Anna A. Brożyna; Robert C. Tuckey

doi:10.1016/j.jid.2017.04.004

Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis

Andrzej T. Slominski, Anna A. Brożyna, Robert C. Tuckey

School of Molecular Sciences

Research output: Contribution to journal › Comment/debate

11 Citations (Scopus)

Abstract

Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.

Original language	English
Pages (from-to)	1609-1611
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	137
Issue number	8
DOIs	https://doi.org/10.1016/j.jid.2017.04.004
Publication status	Published - 1 Aug 2017

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title = "Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis",

abstract = "Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.",

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AU - Slominski, Andrzej T.

AU - Brożyna, Anna A.

AU - Tuckey, Robert C.

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Y1 - 2017/8/1

N2 - Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.

AB - Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.

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M3 - Comment/debate

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EP - 1611

JO - The Journal of Investigative Dermatology

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