Abstract
Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.
| Original language | English |
|---|---|
| Pages (from-to) | 1609-1611 |
| Number of pages | 3 |
| Journal | Journal of Investigative Dermatology |
| Volume | 137 |
| Issue number | 8 |
| DOIs |
|
| Publication status | Published - 1 Aug 2017 |
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Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis. / Slominski, Andrzej T.; Brożyna, Anna A.; Tuckey, Robert C.
In: Journal of Investigative Dermatology, Vol. 137, No. 8, 01.08.2017, p. 1609-1611.Research output: Contribution to journal › Comment/debate
TY - JOUR
T1 - Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis
AU - Slominski, Andrzej T.
AU - Brożyna, Anna A.
AU - Tuckey, Robert C.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.
AB - Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.
UR - http://www.scopus.com/inward/record.url?scp=85024886554&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2017.04.004
DO - 10.1016/j.jid.2017.04.004
M3 - Comment/debate
VL - 137
SP - 1609
EP - 1611
JO - The Journal of Investigative Dermatology
JF - The Journal of Investigative Dermatology
SN - 0022-202X
IS - 8
ER -