Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis

Andrzej T. Slominski, Anna A. Brożyna, Robert C. Tuckey

Research output: Contribution to journalComment/debatepeer-review

13 Citations (Scopus)


Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.

Original languageEnglish
Pages (from-to)1609-1611
Number of pages3
JournalJournal of Investigative Dermatology
Issue number8
Publication statusPublished - 1 Aug 2017


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