Cutaneous drug toxicity from 2,4-dinitrophenol (DNP): Case report and histological description

P. Le; Benjamin Wood; S.P. Kumarasinghe

doi:10.1111/ajd.12237

Cutaneous drug toxicity from 2,4-dinitrophenol (DNP): Case report and histological description

P. Le, Benjamin Wood, S.P. Kumarasinghe

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

© 2014 The Australasian College of Dermatologists. The use of 2,4-dinitrophenol (DNP) has regained popularity as a weight loss aid in the last two decades due to increased marketing to bodybuilders and the increasing availability of this banned substance via the Internet. 2,4-DNP is a drug of narrow therapeutic index and toxicity results in hyperthermia, diaphoresis, tachycardia, tachypnoea and possible cardiac arrest and death. Skin toxicity from 2,4-DNP has not been reported since the 1930s. We report a case of a 21-year-old bodybuilding enthusiast who presented with a toxic exanthem after taking 2,4-DNP, and describe the first skin biopsy findings in a case of 2,4-DNP toxicity.

Original language	English
Pages (from-to)	307-309
Journal	Australasian Journal of Dermatology
Volume	56
Issue number	4
DOIs	https://doi.org/10.1111/ajd.12237
Publication status	Published - 2015

Access to Document

10.1111/ajd.12237

Fingerprint Dive into the research topics of 'Cutaneous drug toxicity from 2,4-dinitrophenol (DNP): Case report and histological description'. Together they form a unique fingerprint.

Cite this

@article{812624dde4524afcb3b48d806f72c34e,

title = "Cutaneous drug toxicity from 2,4-dinitrophenol (DNP): Case report and histological description",

abstract = "{\textcopyright} 2014 The Australasian College of Dermatologists. The use of 2,4-dinitrophenol (DNP) has regained popularity as a weight loss aid in the last two decades due to increased marketing to bodybuilders and the increasing availability of this banned substance via the Internet. 2,4-DNP is a drug of narrow therapeutic index and toxicity results in hyperthermia, diaphoresis, tachycardia, tachypnoea and possible cardiac arrest and death. Skin toxicity from 2,4-DNP has not been reported since the 1930s. We report a case of a 21-year-old bodybuilding enthusiast who presented with a toxic exanthem after taking 2,4-DNP, and describe the first skin biopsy findings in a case of 2,4-DNP toxicity.",

author = "P. Le and Benjamin Wood and S.P. Kumarasinghe",

year = "2015",

doi = "10.1111/ajd.12237",

language = "English",

volume = "56",

pages = "307--309",

journal = "Australian Journal of Dermatology",

issn = "0004-8380",

publisher = "John Wiley & Sons",

number = "4",

}

TY - JOUR

T1 - Cutaneous drug toxicity from 2,4-dinitrophenol (DNP): Case report and histological description

AU - Le, P.

AU - Wood, Benjamin

AU - Kumarasinghe, S.P.

PY - 2015

Y1 - 2015

N2 - © 2014 The Australasian College of Dermatologists. The use of 2,4-dinitrophenol (DNP) has regained popularity as a weight loss aid in the last two decades due to increased marketing to bodybuilders and the increasing availability of this banned substance via the Internet. 2,4-DNP is a drug of narrow therapeutic index and toxicity results in hyperthermia, diaphoresis, tachycardia, tachypnoea and possible cardiac arrest and death. Skin toxicity from 2,4-DNP has not been reported since the 1930s. We report a case of a 21-year-old bodybuilding enthusiast who presented with a toxic exanthem after taking 2,4-DNP, and describe the first skin biopsy findings in a case of 2,4-DNP toxicity.

AB - © 2014 The Australasian College of Dermatologists. The use of 2,4-dinitrophenol (DNP) has regained popularity as a weight loss aid in the last two decades due to increased marketing to bodybuilders and the increasing availability of this banned substance via the Internet. 2,4-DNP is a drug of narrow therapeutic index and toxicity results in hyperthermia, diaphoresis, tachycardia, tachypnoea and possible cardiac arrest and death. Skin toxicity from 2,4-DNP has not been reported since the 1930s. We report a case of a 21-year-old bodybuilding enthusiast who presented with a toxic exanthem after taking 2,4-DNP, and describe the first skin biopsy findings in a case of 2,4-DNP toxicity.

U2 - 10.1111/ajd.12237

DO - 10.1111/ajd.12237

M3 - Article

C2 - 25367505

VL - 56

SP - 307

EP - 309

JO - Australian Journal of Dermatology

JF - Australian Journal of Dermatology

SN - 0004-8380

IS - 4

ER -