Current weight of evidence of viruses associated with peri-implantitis and peri-implant health: A systematic review and meta-analysis

Zohaib Akram, Khulud Abdulrahman Al-Aali, Mohammed Alrabiah, Faisal Abdullah Alonaizan, Tariq Abduljabbar, Fatemah AlAhmari, Fawad Javed, Fahim Vohra

Research output: Contribution to journalReview article

Abstract

The pathological role of human herpesviruses (HHVs) (Epstein-Barr virus [EBV], Human cytomegalovirus [CMV], and Herpes simplex virus [HSV]) in peri-implant health needs clarification quantitatively. To determine the weight of evidence for HHVs in patients with peri-implantitis (PI) and substantiate the significance of HHVs in peri-implant inflammation, electronic databases including EMBASE, MEDLINE, Cochrane Oral Health Group Trials Register, and Cochrane Central Register of Controlled Trials were searched from 1964 up to and including November 2018. Meta-analyses were conducted for prevalence of HHVs in PI and healthy controls. Forest plots were generated that recorded risk difference (RD) of outcomes and 95% confidence intervals (CI). Five clinical studies were considered and included. Four clinical studies reported data on EBV while three clinical studies reported data on CMV. Considering the risk of these viruses in PI, significant heterogeneity for CMV (χ 2  = 53.37, p < 0.0001, I 2  = 96.25%) and EBV (χ 2  = 14.14, p = 0.002, I 2  = 78.79%) prevalence was noticed between PI and healthy control sites. The overall RD for only EBV (RD = 0.20, 95% CI, 0.01-0.40, p = 0.03) was statistically significant between both groups. Frequencies of the viruses were increased in patients with PI compared with healthy nondiseased sites. However, the findings of the present study should be interpreted with caution because of significant heterogeneity and small number of included studies.

Original languageEnglish
Article numbere2042
JournalReviews in Medical Virology
Volume29
Issue number3
DOIs
Publication statusPublished - 1 May 2019

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Peri-Implantitis
Herpesviridae
Meta-Analysis
Human Herpesvirus 4
Viruses
Weights and Measures
Cytomegalovirus
Health
Confidence Intervals
Oral Health
Simplexvirus
MEDLINE
Databases
Inflammation
Clinical Studies

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Akram, Z., Al-Aali, K. A., Alrabiah, M., Alonaizan, F. A., Abduljabbar, T., AlAhmari, F., ... Vohra, F. (2019). Current weight of evidence of viruses associated with peri-implantitis and peri-implant health: A systematic review and meta-analysis. Reviews in Medical Virology, 29(3), [e2042]. https://doi.org/10.1002/rmv.2042
Akram, Zohaib ; Al-Aali, Khulud Abdulrahman ; Alrabiah, Mohammed ; Alonaizan, Faisal Abdullah ; Abduljabbar, Tariq ; AlAhmari, Fatemah ; Javed, Fawad ; Vohra, Fahim. / Current weight of evidence of viruses associated with peri-implantitis and peri-implant health : A systematic review and meta-analysis. In: Reviews in Medical Virology. 2019 ; Vol. 29, No. 3.
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abstract = "The pathological role of human herpesviruses (HHVs) (Epstein-Barr virus [EBV], Human cytomegalovirus [CMV], and Herpes simplex virus [HSV]) in peri-implant health needs clarification quantitatively. To determine the weight of evidence for HHVs in patients with peri-implantitis (PI) and substantiate the significance of HHVs in peri-implant inflammation, electronic databases including EMBASE, MEDLINE, Cochrane Oral Health Group Trials Register, and Cochrane Central Register of Controlled Trials were searched from 1964 up to and including November 2018. Meta-analyses were conducted for prevalence of HHVs in PI and healthy controls. Forest plots were generated that recorded risk difference (RD) of outcomes and 95{\%} confidence intervals (CI). Five clinical studies were considered and included. Four clinical studies reported data on EBV while three clinical studies reported data on CMV. Considering the risk of these viruses in PI, significant heterogeneity for CMV (χ 2  = 53.37, p < 0.0001, I 2  = 96.25{\%}) and EBV (χ 2  = 14.14, p = 0.002, I 2  = 78.79{\%}) prevalence was noticed between PI and healthy control sites. The overall RD for only EBV (RD = 0.20, 95{\%} CI, 0.01-0.40, p = 0.03) was statistically significant between both groups. Frequencies of the viruses were increased in patients with PI compared with healthy nondiseased sites. However, the findings of the present study should be interpreted with caution because of significant heterogeneity and small number of included studies.",
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Akram, Z, Al-Aali, KA, Alrabiah, M, Alonaizan, FA, Abduljabbar, T, AlAhmari, F, Javed, F & Vohra, F 2019, 'Current weight of evidence of viruses associated with peri-implantitis and peri-implant health: A systematic review and meta-analysis' Reviews in Medical Virology, vol. 29, no. 3, e2042. https://doi.org/10.1002/rmv.2042

Current weight of evidence of viruses associated with peri-implantitis and peri-implant health : A systematic review and meta-analysis. / Akram, Zohaib; Al-Aali, Khulud Abdulrahman; Alrabiah, Mohammed; Alonaizan, Faisal Abdullah; Abduljabbar, Tariq; AlAhmari, Fatemah; Javed, Fawad; Vohra, Fahim.

In: Reviews in Medical Virology, Vol. 29, No. 3, e2042, 01.05.2019.

Research output: Contribution to journalReview article

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T1 - Current weight of evidence of viruses associated with peri-implantitis and peri-implant health

T2 - A systematic review and meta-analysis

AU - Akram, Zohaib

AU - Al-Aali, Khulud Abdulrahman

AU - Alrabiah, Mohammed

AU - Alonaizan, Faisal Abdullah

AU - Abduljabbar, Tariq

AU - AlAhmari, Fatemah

AU - Javed, Fawad

AU - Vohra, Fahim

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N2 - The pathological role of human herpesviruses (HHVs) (Epstein-Barr virus [EBV], Human cytomegalovirus [CMV], and Herpes simplex virus [HSV]) in peri-implant health needs clarification quantitatively. To determine the weight of evidence for HHVs in patients with peri-implantitis (PI) and substantiate the significance of HHVs in peri-implant inflammation, electronic databases including EMBASE, MEDLINE, Cochrane Oral Health Group Trials Register, and Cochrane Central Register of Controlled Trials were searched from 1964 up to and including November 2018. Meta-analyses were conducted for prevalence of HHVs in PI and healthy controls. Forest plots were generated that recorded risk difference (RD) of outcomes and 95% confidence intervals (CI). Five clinical studies were considered and included. Four clinical studies reported data on EBV while three clinical studies reported data on CMV. Considering the risk of these viruses in PI, significant heterogeneity for CMV (χ 2  = 53.37, p < 0.0001, I 2  = 96.25%) and EBV (χ 2  = 14.14, p = 0.002, I 2  = 78.79%) prevalence was noticed between PI and healthy control sites. The overall RD for only EBV (RD = 0.20, 95% CI, 0.01-0.40, p = 0.03) was statistically significant between both groups. Frequencies of the viruses were increased in patients with PI compared with healthy nondiseased sites. However, the findings of the present study should be interpreted with caution because of significant heterogeneity and small number of included studies.

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