TY - JOUR
T1 - Current perspectives on the immunopathogenesis of sarcoidosis
AU - Lee, Silvia
AU - Birnie, David
AU - Dwivedi, Girish
PY - 2020/11
Y1 - 2020/11
N2 - Sarcoidosis is an inflammatory systemic disease that commonly affects the lungs or lymph nodes but can manifest in other organs. Herein, we review the latest evidence establishing how innate and adaptive immune responses contribute to the pathogenesis and clinical course of sarcoidosis. We discuss the possible role of microbial organisms as etiologic agents in sarcoidosis and the evidence supporting sarcoidosis as an autoimmune disease. We also discuss how animal and in vitro human models have advanced our understanding of the immunopathogenesis of sarcoidosis. Finally, we discuss therapeutics for sarcoidosis and the effects on the immune system.
AB - Sarcoidosis is an inflammatory systemic disease that commonly affects the lungs or lymph nodes but can manifest in other organs. Herein, we review the latest evidence establishing how innate and adaptive immune responses contribute to the pathogenesis and clinical course of sarcoidosis. We discuss the possible role of microbial organisms as etiologic agents in sarcoidosis and the evidence supporting sarcoidosis as an autoimmune disease. We also discuss how animal and in vitro human models have advanced our understanding of the immunopathogenesis of sarcoidosis. Finally, we discuss therapeutics for sarcoidosis and the effects on the immune system.
KW - Adaptive immune responses
KW - Innate immune responses
KW - Sarcoidosis
UR - http://www.scopus.com/inward/record.url?scp=85091594223&partnerID=8YFLogxK
U2 - 10.1016/j.rmed.2020.106161
DO - 10.1016/j.rmed.2020.106161
M3 - Review article
C2 - 32992264
AN - SCOPUS:85091594223
VL - 173
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
M1 - 106161
ER -
