Current perspectives on the immunopathogenesis of sarcoidosis

Silvia Lee, David Birnie, Girish Dwivedi

Research output: Contribution to journalReview article

Abstract

Sarcoidosis is an inflammatory systemic disease that commonly affects the lungs or lymph nodes but can manifest in other organs. Herein, we review the latest evidence establishing how innate and adaptive immune responses contribute to the pathogenesis and clinical course of sarcoidosis. We discuss the possible role of microbial organisms as etiologic agents in sarcoidosis and the evidence supporting sarcoidosis as an autoimmune disease. We also discuss how animal and in vitro human models have advanced our understanding of the immunopathogenesis of sarcoidosis. Finally, we discuss therapeutics for sarcoidosis and the effects on the immune system.

Original languageEnglish
Article number106161
JournalRespiratory Medicine
Volume173
DOIs
Publication statusPublished - Nov 2020

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