Current Epigenetic Therapy for T-Cell Lymphoma

Michael Dickinson, Chan Cheah, H. Miles Prince

Research output: Chapter in Book/Conference paperChapter

1 Citation (Scopus)

Abstract

Cutaneous T-cell lymphoma (CTCL) is challenging to treat. Patients with advanced disease typically only enjoy brief responses to conventional chemotherapeutics, and are at particularly high risk of infectious complications during the treatment with chemotherapy. Combination and intensification of conventional chemotherapeutics fails to cure the vast majority of patients with CTCL or other forms of peripheral T-cell lymphoma (PTCL). In this context, biological agents, and in particular the histone deacetylase inhibitors (HDACis), present an attractive alternative because they lack many of the side effects of conventional chemotherapy and appear to overcome chemotherapy resistance.

The HDACis target not only the epigenome but also numerous nucleic and cytoplasmic non-histone proteins and are powerful and selective inducers of cancer cell apoptosis and modifiers of the tumour microenvironment. To date, the best data for their use comes from trials in the lymphoid malignancies and CTCL is the only condition for which HDACis are currently registered. The FDA has approved romidepsin and vorinostat for use in relapsed/refractory CTCL and these agents provide patients with a new opportunity for durable clinical response. Similarly, romidepsin has potent activity in nodal PTCLs, with emerging data supporting a future role in clinical practice, either alone or in combination with conventional therapies.

Here we discuss the concept of epigenetic modifying agents, briefly review the putative targets for the HDACis and discuss key clinical trials supporting their use in T-cell lymphoma.
Original languageEnglish
Title of host publicationT-Cell Lymphomas
EditorsFrancine Foss
Place of PublicationUnited States
PublisherHumana Press
Chapter16
Pages279-296
ISBN (Electronic)9781627031707
ISBN (Print)9781627031691
DOIs
Publication statusPublished - 2013
Externally publishedYes

Publication series

NameContemporary Hematology

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  • Cite this

    Dickinson, M., Cheah, C., & Prince, H. M. (2013). Current Epigenetic Therapy for T-Cell Lymphoma. In F. Foss (Ed.), T-Cell Lymphomas (pp. 279-296). (Contemporary Hematology). Humana Press. https://doi.org/10.1007/978-1-62703-170-7_16