Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies

Hajar Heidari, Mohammad Bagherniya, Muhammed Majeed, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)

Abstract

Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti-inflammatory and anti-oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioavailability. Co-administration of curcumin along with piperine could potentially improve the bioavailability of curcumin. The present review aimed to provide an overview of the efficacy and safety of curcumin-piperine co-supplementation in human health. The findings of this comprehensive review show the beneficial effects of curcumin-piperine in improving glycemic indices, lipid profile and antioxidant status in diabetes, improving the inflammatory status caused by obesity and metabolic syndrome, reducing oxidative stress and depression in chronic stress and neurological disorders, also improving chronic respiratory diseases, asthma and COVID-19. Further high-quality clinical trial studies are needed to firmly establish the clinical efficacy of the curcumin-piperine supplement.
Original languageEnglish
Pages (from-to)1462-1487
Number of pages26
JournalPhytotherapy Research
Volume37
Issue number4
DOIs
Publication statusPublished - Apr 2023

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