TY - JOUR
T1 - Curcumin-piperine co-supplementation and human health
T2 - A comprehensive review of preclinical and clinical studies
AU - Heidari, Hajar
AU - Bagherniya, Mohammad
AU - Majeed, Muhammed
AU - Sathyapalan, Thozhukat
AU - Jamialahmadi, Tannaz
AU - Sahebkar, Amirhossein
N1 - Publisher Copyright:
© 2023 John Wiley & Sons Ltd.
PY - 2023/4
Y1 - 2023/4
N2 - Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti-inflammatory and anti-oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioavailability. Co-administration of curcumin along with piperine could potentially improve the bioavailability of curcumin. The present review aimed to provide an overview of the efficacy and safety of curcumin-piperine co-supplementation in human health. The findings of this comprehensive review show the beneficial effects of curcumin-piperine in improving glycemic indices, lipid profile and antioxidant status in diabetes, improving the inflammatory status caused by obesity and metabolic syndrome, reducing oxidative stress and depression in chronic stress and neurological disorders, also improving chronic respiratory diseases, asthma and COVID-19. Further high-quality clinical trial studies are needed to firmly establish the clinical efficacy of the curcumin-piperine supplement.
AB - Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti-inflammatory and anti-oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioavailability. Co-administration of curcumin along with piperine could potentially improve the bioavailability of curcumin. The present review aimed to provide an overview of the efficacy and safety of curcumin-piperine co-supplementation in human health. The findings of this comprehensive review show the beneficial effects of curcumin-piperine in improving glycemic indices, lipid profile and antioxidant status in diabetes, improving the inflammatory status caused by obesity and metabolic syndrome, reducing oxidative stress and depression in chronic stress and neurological disorders, also improving chronic respiratory diseases, asthma and COVID-19. Further high-quality clinical trial studies are needed to firmly establish the clinical efficacy of the curcumin-piperine supplement.
KW - clinical
KW - curcumin
KW - health
KW - piperine
KW - preclinical
UR - http://www.scopus.com/inward/record.url?scp=85147336599&partnerID=8YFLogxK
U2 - 10.1002/ptr.7737
DO - 10.1002/ptr.7737
M3 - Review article
C2 - 36720711
AN - SCOPUS:85147336599
SN - 0951-418X
VL - 37
SP - 1462
EP - 1487
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 4
ER -