TY - JOUR
T1 - Curcumin and chemokines
T2 - mechanism of action and therapeutic potential in inflammatory diseases
AU - Sadeghi, Mahvash
AU - Dehnavi, Sajad
AU - Asadirad, Ali
AU - Xu, Suowen
AU - Majeed, Muhammed
AU - Jamialahmadi, Tannaz
AU - Johnston, Thomas P.
AU - Sahebkar, Amirhossein
PY - 2023/6
Y1 - 2023/6
N2 - Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties. Chemokines and chemokine receptors are influenced/modulated by curcumin. Thus, the current review focuses on the molecular mechanisms associated with curcumin's effects on chemoattractant cytokines, as well as putting into context the many studies that have reported curcumin-mediated regulatory effects on inflammatory conditions in the organs/systems of the body (e.g., the central nervous system, liver, and cardiovascular system). Curcumin's effects on viral and bacterial infections, cancer, and adverse pregnancy outcomes are also reviewed.
AB - Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties. Chemokines and chemokine receptors are influenced/modulated by curcumin. Thus, the current review focuses on the molecular mechanisms associated with curcumin's effects on chemoattractant cytokines, as well as putting into context the many studies that have reported curcumin-mediated regulatory effects on inflammatory conditions in the organs/systems of the body (e.g., the central nervous system, liver, and cardiovascular system). Curcumin's effects on viral and bacterial infections, cancer, and adverse pregnancy outcomes are also reviewed.
KW - Cancer
KW - Chemokine
KW - Curcumin
KW - Cytokine
KW - Infection
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=85151341861&partnerID=8YFLogxK
U2 - 10.1007/s10787-023-01136-w
DO - 10.1007/s10787-023-01136-w
M3 - Review article
C2 - 36997729
AN - SCOPUS:85151341861
SN - 0925-4692
VL - 31
SP - 1069
EP - 1093
JO - Inflammopharmacology
JF - Inflammopharmacology
IS - 3
ER -
