Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases

Mahvash Sadeghi, Sajad Dehnavi, Ali Asadirad, Suowen Xu, Muhammed Majeed, Tannaz Jamialahmadi, Thomas P. Johnston, Amirhossein Sahebkar

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties. Chemokines and chemokine receptors are influenced/modulated by curcumin. Thus, the current review focuses on the molecular mechanisms associated with curcumin's effects on chemoattractant cytokines, as well as putting into context the many studies that have reported curcumin-mediated regulatory effects on inflammatory conditions in the organs/systems of the body (e.g., the central nervous system, liver, and cardiovascular system). Curcumin's effects on viral and bacterial infections, cancer, and adverse pregnancy outcomes are also reviewed.

Original languageEnglish
Pages (from-to)1069-1093
Number of pages25
JournalInflammopharmacology
Volume31
Issue number3
Early online date30 Mar 2023
DOIs
Publication statusPublished - Jun 2023

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