Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity

Ramin Rezaee, Amir Abbas Momtazi, Alireza Monemi, Amirhossein Sahebkar

    Research output: Contribution to journalReview article

    94 Citations (Scopus)

    Abstract

    Curcumin is a naturally occurring polyphenol isolated from Curcuma longa that has gained considerable interest over the last decades due to its beneficial effects for human health. Moreover, the usage of cisplatin, a platinum-based chemotherapeutic, is associated with several adverse effects affecting the quality of life of the patients. Also, cisplatin therapy is jeopardized by a great challenge of resistance which reduces the efficacy of this drug. In order to conquer these dark sides of cisplatin therapy, curcumin has been widely used to fight against cisplatin-resistant cancer cells and decrease its unwanted side effects (e.g. ototoxicity, nephrotoxicity and neurotoxicity). In this review, we provide a summary of the studies done to show the protective effects of curcumin against cisplatin failure and toxicity.

    Original languageEnglish
    Pages (from-to)218-227
    Number of pages10
    JournalPharmacological Research
    Volume117
    DOIs
    Publication statusPublished - 1 Mar 2017

    Fingerprint Dive into the research topics of 'Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity'. Together they form a unique fingerprint.

  • Cite this