Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity

Peter Peeling, Brian Dawson, C. Goodman, Grant Landers, E.T. Wiegerinck, D.W. Swinkels, Debbie Trinder

    Research output: Contribution to journalArticle

    64 Citations (Scopus)

    Abstract

    The effect of two running sessions completedwithin a 12-h period on hemolysis, inflammation, and hepcidinactivity in endurance athletes was investigated. Tenmales completed two experimental trials in a randomized,counterbalanced order. The two trials included (a) a onerunning-session trial (T1) including 10 9 1 km intervalrepeats (90% peak _V O2 velocity), and (b) a two-runningsessiontrial (T2), comprising a continuous 10-km run (70%peak _V O2 velocity), and a 10 9 1 kminterval run (90% peak_VO2 velocity) completed 12 h later. Interleukin-6 (IL-6),free hemoglobin (Hb), haptoglobin (Hp), iron, ferritin, andhepcidin were assessed post-exercise. After the T1 and T2interval runs, free Hb was significantly increased and Hpsignificantly decreased (p B 0.05), with a cumulative effectshown in T2 after the second run (p B 0.05). The IL-6, serumiron, ferritin, and hepcidin activity were increased after eachrunning session (p B 0.05), with no cumulative effect in T2.In conclusion, a cumulative effect of two running sessions onhemolysis was shown, but no similar effect with inflammationand hepcidin activity was evident.
    Original languageEnglish
    Pages (from-to)on-line
    JournalEuropean Journal of Applied Physiology
    Volume106
    Issue number1
    DOIs
    Publication statusPublished - 2009

    Fingerprint

    Hepcidins
    Ferritins
    Hemolysis
    Running
    Interleukin-6
    Hemoglobins
    Inflammation
    Haptoglobins
    Athletes
    Iron
    Exercise

    Cite this

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    abstract = "The effect of two running sessions completedwithin a 12-h period on hemolysis, inflammation, and hepcidinactivity in endurance athletes was investigated. Tenmales completed two experimental trials in a randomized,counterbalanced order. The two trials included (a) a onerunning-session trial (T1) including 10 9 1 km intervalrepeats (90{\%} peak _V O2 velocity), and (b) a two-runningsessiontrial (T2), comprising a continuous 10-km run (70{\%}peak _V O2 velocity), and a 10 9 1 kminterval run (90{\%} peak_VO2 velocity) completed 12 h later. Interleukin-6 (IL-6),free hemoglobin (Hb), haptoglobin (Hp), iron, ferritin, andhepcidin were assessed post-exercise. After the T1 and T2interval runs, free Hb was significantly increased and Hpsignificantly decreased (p B 0.05), with a cumulative effectshown in T2 after the second run (p B 0.05). The IL-6, serumiron, ferritin, and hepcidin activity were increased after eachrunning session (p B 0.05), with no cumulative effect in T2.In conclusion, a cumulative effect of two running sessions onhemolysis was shown, but no similar effect with inflammationand hepcidin activity was evident.",
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    Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity. / Peeling, Peter; Dawson, Brian; Goodman, C.; Landers, Grant; Wiegerinck, E.T.; Swinkels, D.W.; Trinder, Debbie.

    In: European Journal of Applied Physiology, Vol. 106, No. 1, 2009, p. on-line.

    Research output: Contribution to journalArticle

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    AU - Peeling, Peter

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    AU - Swinkels, D.W.

    AU - Trinder, Debbie

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