Cruciferous and total vegetable intakes are inversely associated with subclinical atherosclerosis in older adult women

Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua R. Lewis, Richard J. Woodman, Amanda Devine, Nicola P. Bondonno, Wai H. Lim, Kun Zhu, Lawrence J. Beilin, Peter L. Thompson, Richard L. Prince, Jonathan M. Hodgson

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Abstract

Background--Dietary patterns rich in fruits and vegetables are considered to reduce atherosclerotic disease presentation and are reported to be inversely associated with subclinical measures of atherosclerosis, such as carotid artery intima-media thickness (IMT) and plaque. However, the effect of vegetable intake alone, and relationships to specific types of vegetables containing different phytochemical profiles, is important. The aim of this study was to investigate the associations of total vegetable intake and specific vegetables grouped according to phytochemical constituents with common carotid artery IMT (CCA-IMT) and carotid plaque severity in a cohort of older adult women (aged ≥70 years). Methods and Results--Total vegetable intake was calculated at baseline (1998) using a validated food frequency questionnaire. Vegetable types included cruciferous, allium, yellow/orange/red, leafy green, and legumes. In 2001, CCA-IMT (n=954) and carotid focal plaque (n=968) were assessed using high-resolution B-mode carotid ultrasonography. Mean (SD) total vegetable intake was 199.9 (78.0) g/d. Women consuming ≥3 servings of vegetables each day had ≈4.6% to 5.0% lower mean CCA-IMT (P=0.014) and maximum CCA-IMT (P=0.004) compared with participants consuming < 2 servings of vegetables. For each 10 g/d higher in cruciferous vegetable intake, there was an associated 0.006 mm (0.8%) lower mean CCA-IMT (P < 0.01) and 0.007 mm (0.8%) lower maximum CCA-IMT (P < 0.01). Other vegetable types were not associated with CCA-IMT (P > 0.05). No associations were observed between vegetables and plaque severity (P > 0.05). Conclusions--Increasing vegetables in the diet with a focus on consuming cruciferous vegetables may have benefits for the prevention of subclinical atherosclerosis in older adult women.

Original languageEnglish
Article numbere008391
JournalJournal of the American Heart Association
Volume7
Issue number8
DOIs
Publication statusPublished - 17 Apr 2018

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Vegetables
Atherosclerosis
Common Carotid Artery
Carotid Intima-Media Thickness
Phytochemicals
Allium
Carotid Arteries
Fabaceae
Ultrasonography
Fruit
Diet
Food

Cite this

@article{15ff2c495cf24166a5588ff7ae1f3423,
title = "Cruciferous and total vegetable intakes are inversely associated with subclinical atherosclerosis in older adult women",
abstract = "Background--Dietary patterns rich in fruits and vegetables are considered to reduce atherosclerotic disease presentation and are reported to be inversely associated with subclinical measures of atherosclerosis, such as carotid artery intima-media thickness (IMT) and plaque. However, the effect of vegetable intake alone, and relationships to specific types of vegetables containing different phytochemical profiles, is important. The aim of this study was to investigate the associations of total vegetable intake and specific vegetables grouped according to phytochemical constituents with common carotid artery IMT (CCA-IMT) and carotid plaque severity in a cohort of older adult women (aged ≥70 years). Methods and Results--Total vegetable intake was calculated at baseline (1998) using a validated food frequency questionnaire. Vegetable types included cruciferous, allium, yellow/orange/red, leafy green, and legumes. In 2001, CCA-IMT (n=954) and carotid focal plaque (n=968) were assessed using high-resolution B-mode carotid ultrasonography. Mean (SD) total vegetable intake was 199.9 (78.0) g/d. Women consuming ≥3 servings of vegetables each day had ≈4.6{\%} to 5.0{\%} lower mean CCA-IMT (P=0.014) and maximum CCA-IMT (P=0.004) compared with participants consuming < 2 servings of vegetables. For each 10 g/d higher in cruciferous vegetable intake, there was an associated 0.006 mm (0.8{\%}) lower mean CCA-IMT (P < 0.01) and 0.007 mm (0.8{\%}) lower maximum CCA-IMT (P < 0.01). Other vegetable types were not associated with CCA-IMT (P > 0.05). No associations were observed between vegetables and plaque severity (P > 0.05). Conclusions--Increasing vegetables in the diet with a focus on consuming cruciferous vegetables may have benefits for the prevention of subclinical atherosclerosis in older adult women.",
keywords = "Atherosclerosis, Carotid intima-media thickness, Carotid plaque, Cruciferous, Vegetables",
author = "Blekkenhorst, {Lauren C.} and Bondonno, {Catherine P.} and Lewis, {Joshua R.} and Woodman, {Richard J.} and Amanda Devine and Bondonno, {Nicola P.} and Lim, {Wai H.} and Kun Zhu and Beilin, {Lawrence J.} and Thompson, {Peter L.} and Prince, {Richard L.} and Hodgson, {Jonathan M.}",
year = "2018",
month = "4",
day = "17",
doi = "10.1161/JAHA.117.008391",
language = "English",
volume = "7",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "John Wiley & Sons",
number = "8",

}

TY - JOUR

T1 - Cruciferous and total vegetable intakes are inversely associated with subclinical atherosclerosis in older adult women

AU - Blekkenhorst, Lauren C.

AU - Bondonno, Catherine P.

AU - Lewis, Joshua R.

AU - Woodman, Richard J.

AU - Devine, Amanda

AU - Bondonno, Nicola P.

AU - Lim, Wai H.

AU - Zhu, Kun

AU - Beilin, Lawrence J.

AU - Thompson, Peter L.

AU - Prince, Richard L.

AU - Hodgson, Jonathan M.

PY - 2018/4/17

Y1 - 2018/4/17

N2 - Background--Dietary patterns rich in fruits and vegetables are considered to reduce atherosclerotic disease presentation and are reported to be inversely associated with subclinical measures of atherosclerosis, such as carotid artery intima-media thickness (IMT) and plaque. However, the effect of vegetable intake alone, and relationships to specific types of vegetables containing different phytochemical profiles, is important. The aim of this study was to investigate the associations of total vegetable intake and specific vegetables grouped according to phytochemical constituents with common carotid artery IMT (CCA-IMT) and carotid plaque severity in a cohort of older adult women (aged ≥70 years). Methods and Results--Total vegetable intake was calculated at baseline (1998) using a validated food frequency questionnaire. Vegetable types included cruciferous, allium, yellow/orange/red, leafy green, and legumes. In 2001, CCA-IMT (n=954) and carotid focal plaque (n=968) were assessed using high-resolution B-mode carotid ultrasonography. Mean (SD) total vegetable intake was 199.9 (78.0) g/d. Women consuming ≥3 servings of vegetables each day had ≈4.6% to 5.0% lower mean CCA-IMT (P=0.014) and maximum CCA-IMT (P=0.004) compared with participants consuming < 2 servings of vegetables. For each 10 g/d higher in cruciferous vegetable intake, there was an associated 0.006 mm (0.8%) lower mean CCA-IMT (P < 0.01) and 0.007 mm (0.8%) lower maximum CCA-IMT (P < 0.01). Other vegetable types were not associated with CCA-IMT (P > 0.05). No associations were observed between vegetables and plaque severity (P > 0.05). Conclusions--Increasing vegetables in the diet with a focus on consuming cruciferous vegetables may have benefits for the prevention of subclinical atherosclerosis in older adult women.

AB - Background--Dietary patterns rich in fruits and vegetables are considered to reduce atherosclerotic disease presentation and are reported to be inversely associated with subclinical measures of atherosclerosis, such as carotid artery intima-media thickness (IMT) and plaque. However, the effect of vegetable intake alone, and relationships to specific types of vegetables containing different phytochemical profiles, is important. The aim of this study was to investigate the associations of total vegetable intake and specific vegetables grouped according to phytochemical constituents with common carotid artery IMT (CCA-IMT) and carotid plaque severity in a cohort of older adult women (aged ≥70 years). Methods and Results--Total vegetable intake was calculated at baseline (1998) using a validated food frequency questionnaire. Vegetable types included cruciferous, allium, yellow/orange/red, leafy green, and legumes. In 2001, CCA-IMT (n=954) and carotid focal plaque (n=968) were assessed using high-resolution B-mode carotid ultrasonography. Mean (SD) total vegetable intake was 199.9 (78.0) g/d. Women consuming ≥3 servings of vegetables each day had ≈4.6% to 5.0% lower mean CCA-IMT (P=0.014) and maximum CCA-IMT (P=0.004) compared with participants consuming < 2 servings of vegetables. For each 10 g/d higher in cruciferous vegetable intake, there was an associated 0.006 mm (0.8%) lower mean CCA-IMT (P < 0.01) and 0.007 mm (0.8%) lower maximum CCA-IMT (P < 0.01). Other vegetable types were not associated with CCA-IMT (P > 0.05). No associations were observed between vegetables and plaque severity (P > 0.05). Conclusions--Increasing vegetables in the diet with a focus on consuming cruciferous vegetables may have benefits for the prevention of subclinical atherosclerosis in older adult women.

KW - Atherosclerosis

KW - Carotid intima-media thickness

KW - Carotid plaque

KW - Cruciferous

KW - Vegetables

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U2 - 10.1161/JAHA.117.008391

DO - 10.1161/JAHA.117.008391

M3 - Article

VL - 7

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 8

M1 - e008391

ER -