Abstract
Background--Higher vegetable intake is consistently associated with lower atherosclerotic vascular disease (ASVD) events. However, the components responsible and mechanisms involved are uncertain. Nonnutritive phytochemicals may be involved. The objective of this study was to investigate the associations of total vegetable intake and types of vegetables grouped according to phytochemical constituents with ASVD mortality. Methods and Results--The cohort consisted of 1226 Australian women aged 70 years and older without clinical ASVD or diabetes mellitus at baseline (1998). Vegetable intakes were calculated per serving (75 g/d) and were also classified into prespecified types relating to phytochemical constituents. ASVD-related deaths were ascertained from linked mortality data. During 15 years (15 947 person-years) of follow-up, 238 ASVD-related deaths occurred. A 1-serving increment of vegetable intake was associated with a 20% lower hazard of ASVD-related death (multivariable-adjusted hazard ratio, 0.80; 95% confidence interval, 0.69-0.94 [P=0.005]). In multivariable-adjusted models for vegetable types, cruciferous (per 10-g/d increase: hazard ratio, 0.87; 95% confidence interval, 0.81-0.94 [P
| Original language | English |
|---|---|
| Article number | e006558 |
| Journal | Journal of the American Heart Association |
| Volume | 6 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1 Oct 2017 |
Fingerprint
Cite this
}
Cruciferous and allium vegetable intakes are inversely associated with 15-Year atherosclerotic vascular disease deaths in older adult women. / Blekkenhorst, Lauren C.; Bondonno, Catherine P.; Lewis, Joshua R.; Devine, Amanda; Zhu, Kun; Lim, Wai H.; Woodman, Richard J.; Beilin, Lawrence J.; Prince, Richard L.; Hodgson, Jonathan M.
In: Journal of the American Heart Association, Vol. 6, No. 10, e006558, 01.10.2017.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cruciferous and allium vegetable intakes are inversely associated with 15-Year atherosclerotic vascular disease deaths in older adult women
AU - Blekkenhorst, Lauren C.
AU - Bondonno, Catherine P.
AU - Lewis, Joshua R.
AU - Devine, Amanda
AU - Zhu, Kun
AU - Lim, Wai H.
AU - Woodman, Richard J.
AU - Beilin, Lawrence J.
AU - Prince, Richard L.
AU - Hodgson, Jonathan M.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Background--Higher vegetable intake is consistently associated with lower atherosclerotic vascular disease (ASVD) events. However, the components responsible and mechanisms involved are uncertain. Nonnutritive phytochemicals may be involved. The objective of this study was to investigate the associations of total vegetable intake and types of vegetables grouped according to phytochemical constituents with ASVD mortality. Methods and Results--The cohort consisted of 1226 Australian women aged 70 years and older without clinical ASVD or diabetes mellitus at baseline (1998). Vegetable intakes were calculated per serving (75 g/d) and were also classified into prespecified types relating to phytochemical constituents. ASVD-related deaths were ascertained from linked mortality data. During 15 years (15 947 person-years) of follow-up, 238 ASVD-related deaths occurred. A 1-serving increment of vegetable intake was associated with a 20% lower hazard of ASVD-related death (multivariable-adjusted hazard ratio, 0.80; 95% confidence interval, 0.69-0.94 [P=0.005]). In multivariable-adjusted models for vegetable types, cruciferous (per 10-g/d increase: hazard ratio, 0.87; 95% confidence interval, 0.81-0.94 [P
AB - Background--Higher vegetable intake is consistently associated with lower atherosclerotic vascular disease (ASVD) events. However, the components responsible and mechanisms involved are uncertain. Nonnutritive phytochemicals may be involved. The objective of this study was to investigate the associations of total vegetable intake and types of vegetables grouped according to phytochemical constituents with ASVD mortality. Methods and Results--The cohort consisted of 1226 Australian women aged 70 years and older without clinical ASVD or diabetes mellitus at baseline (1998). Vegetable intakes were calculated per serving (75 g/d) and were also classified into prespecified types relating to phytochemical constituents. ASVD-related deaths were ascertained from linked mortality data. During 15 years (15 947 person-years) of follow-up, 238 ASVD-related deaths occurred. A 1-serving increment of vegetable intake was associated with a 20% lower hazard of ASVD-related death (multivariable-adjusted hazard ratio, 0.80; 95% confidence interval, 0.69-0.94 [P=0.005]). In multivariable-adjusted models for vegetable types, cruciferous (per 10-g/d increase: hazard ratio, 0.87; 95% confidence interval, 0.81-0.94 [P
KW - Allium
KW - Atherosclerosis
KW - Atherosclerotic vascular disease
KW - Cardiovascular events
KW - Cruciferous
KW - Diet
KW - Follow-up study
KW - Observational studies
KW - Vegetables
UR - http://www.scopus.com/inward/record.url?scp=85032218927&partnerID=8YFLogxK
U2 - 10.1161/JAHA.117.006558
DO - 10.1161/JAHA.117.006558
M3 - Article
VL - 6
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 10
M1 - e006558
ER -