Projects per year
Abstract
CONTEXT: Telomeres protect chromosomes from damage, and shorter leucocyte telomere length (LTL) is a marker of advancing biological age. The association between testosterone (T) and its bioactive metabolites, dihydrotestosterone (DHT) and estradiol (E2) with telomere length, particularly in older men, is uncertain. The study aimed to clarify associations of sex hormones with LTL in older men.
PARTICIPANTS AND METHODS: We used cross-sectional data from 2,913 men aged 76.7±3.2 years with morning blood samples assayed for T, DHT, E2 (mass spectrometry), and sex hormone-binding globulin (SHBG, immunoassay), to correlate sex hormones with LTL measured using PCR and expressed as T/S ratio in multivariable linear regression models adjusted for age, cardiometabolic risk factors and cardiovascular disease history.
RESULTS: Average difference per decade of age was T -0.46 nmol/L, DHT -0.11 nmol/L, E2 -7.5 pmol/L, SHBG +10.2 nmol/L, and LTL (T/S ratio) -0.065. E2 correlated with T/S ratio (r=0.038, p=0.039) and SHBG was inversely correlated (r=-0.053, p=0.004). After multivariable adjustment, E2 was associated with T/S ratio (per 1SD increase E2: coefficient 0.011, p=0.043), T and DHT were not associated. When E2 and SHBG were simultaneously included, E2 remained positively (coefficient 0.014, p=0.014) and SHBG inversely (coefficient -0.013, p=0.037) associated with T/S ratio.
CONCLUSIONS: In older men, neither T nor DHT are associated with LTL while E2 is independently associated with LTL and SHBG is inversely associated, thus relating sex hormone exposure to lower biological age. Further research is needed to determine causality and clarify the role of sex hormones in male ageing. This article is protected by copyright. All rights reserved.
Original language | English |
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Pages (from-to) | 562-569 |
Number of pages | 8 |
Journal | Clinical Endocrinology |
Volume | 90 |
Issue number | 4 |
Early online date | 20 Jan 2019 |
DOIs | |
Publication status | Published - Apr 2019 |
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Dive into the research topics of 'Cross-sectional associations of sex hormones with leucocyte telomere length, a marker of biological age, in a community-based cohort of older men'. Together they form a unique fingerprint.Projects
- 3 Finished
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Reaching the tenth decade of life in Australia – A 20-year longitudinal study of older men
Flicker, L. (Investigator 01), De Almeida, O. (Investigator 02), Yeap, B. (Investigator 03), Robinson, S. (Investigator 04), Etherton-Beer, C. (Investigator 05) & Alfonso, H. (Investigator 06)
NHMRC National Health and Medical Research Council
1/01/17 → 30/06/22
Project: Research
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Do sex hormones slow biological ageing to improve health outcomes in men?
Yeap, B. (Investigator 01), Beilby, J. (Investigator 02), Hui, J. (Investigator 03), Knuiman, M. (Investigator 04) & Flicker, L. (Investigator 05)
NHMRC National Health and Medical Research Council
1/01/17 → 31/12/19
Project: Research
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Trajectories of circulating testosterone and estradiol and implications for the health of ageing men
Yeap, B. (Investigator 01), Flicker, L. (Investigator 02) & McCaul, K. (Investigator 03)
NHMRC National Health and Medical Research Council
1/01/14 → 30/06/16
Project: Research