Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103 and XCR1+CD103+ dendritic cells

Ben Wylie, Elke Seppanen, K. Xiao, Rachael Zemek, D. Zanker, S. Prato, Bree Foley, Prudence Hart, R.A. Kroczek, W. Chen, Jason Waithman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

© 2015 Taylor & Francis Group, LLC. The question of which dendritic cells (DCs) cross-present peripheral tumor antigens remains unanswered. We assessed the ability of multiple skin-derived and lymphoid resident DCs to perform this function in a novel orthotopic murine melanoma model where tumor establishment and expansion is within the skin. Two migratory populations defined as CD103XCR1+ and CD103+XCR1+ efficiently cross-presented melanoma-derived antigen, with the CD103XCR1+ DCs surprisingly dominating this process. These results are critical for understanding how antitumor CD8+ T cell immunity is coordinated to tumor antigens present within the skin.
Original languageEnglish
Pages (from-to)1-11
JournalOncoImmunology
Volume4
Issue number8
DOIs
Publication statusPublished - 2015

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