TY - JOUR
T1 - Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220
AU - Du, Feng Yu
AU - Li, Xiao Ming
AU - Li, Chun Shun
AU - Shang, Zhuo
AU - Wang, Bin Gui
PY - 2012/7/15
Y1 - 2012/7/15
N2 - Four new indole alkaloids, namely, cristatumins A-D (1-4), along with six known congeners (5-10) were identified from the culture extract of Eurotium cristatum EN-220, an endophytic fungus isolated from the marine alga Sargassum thunbergii. The structures of these compounds were established on the basis of extensive spectroscopic analysis. Each of these compounds was evaluated for antimicrobial and insecticidal activity. Compounds 1 and 9 showed antibacterial activity against Escherichia coli and Staphyloccocus aureus, respectively, while compounds 2, 6, and 7 exhibited moderate lethal activity against brine shrimp. Preliminary structure-activity relationships were also discussed.
AB - Four new indole alkaloids, namely, cristatumins A-D (1-4), along with six known congeners (5-10) were identified from the culture extract of Eurotium cristatum EN-220, an endophytic fungus isolated from the marine alga Sargassum thunbergii. The structures of these compounds were established on the basis of extensive spectroscopic analysis. Each of these compounds was evaluated for antimicrobial and insecticidal activity. Compounds 1 and 9 showed antibacterial activity against Escherichia coli and Staphyloccocus aureus, respectively, while compounds 2, 6, and 7 exhibited moderate lethal activity against brine shrimp. Preliminary structure-activity relationships were also discussed.
KW - Antimicrobial activity
KW - Brine shrimp inhibition
KW - Eurotium cristatum
KW - Indole alkaloid
KW - Marine endophyte
UR - http://www.scopus.com/inward/record.url?scp=84863470854&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2012.05.088
DO - 10.1016/j.bmcl.2012.05.088
M3 - Article
C2 - 22727636
AN - SCOPUS:84863470854
SN - 0960-894X
VL - 22
SP - 4650
EP - 4653
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 14
ER -
