Creating Chronic Tympanic Membrane Perforations in a Rat Model

Yu-Yu Wang

doi:10.4225/23/5a29e8242810c

Creating Chronic Tympanic Membrane Perforations in a Rat Model

Yu-Yu Wang

Research output: Thesis › Doctoral Thesis

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Abstract

Tympanic membrane perforation (TMP) is a common pathology. Most TMPs heal spontaneously within 10 days. Those that fail to heal within three months are defined as chronic TMPs which surgical grafting is an option tor treatment, typically with autografts. The development of new graft materials for tympanic membrane repair requires in vivo (i.o. animal models) evaluations prior to clinical trials. In order to examine the efficacy of a novel graft, a chronic TMP animal model mimicking clinical condition of chronic TMPs Is required. The aim of this study was to develop techniques for creating a chronic TMP model in rats.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Dilley, Rodney, Supervisor Atlas, Marcus, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	8 Nov 2017
DOIs	https://doi.org/10.4225/23/5a29e8242810c
Publication status	Unpublished - 2017

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THESIS - DOCTOR OF PHILOSOPHY - WANG Yu-Yu - 2017
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Cite this

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title = "Creating Chronic Tympanic Membrane Perforations in a Rat Model",

abstract = "Tympanic membrane perforation (TMP) is a common pathology. Most TMPs heal spontaneously within 10 days. Those that fail to heal within three months are defined as chronic TMPs which surgical grafting is an option tor treatment, typically with autografts. The development of new graft materials for tympanic membrane repair requires in vivo (i.o. animal models) evaluations prior to clinical trials. In order to examine the efficacy of a novel graft, a chronic TMP animal model mimicking clinical condition of chronic TMPs Is required. The aim of this study was to develop techniques for creating a chronic TMP model in rats.",

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N2 - Tympanic membrane perforation (TMP) is a common pathology. Most TMPs heal spontaneously within 10 days. Those that fail to heal within three months are defined as chronic TMPs which surgical grafting is an option tor treatment, typically with autografts. The development of new graft materials for tympanic membrane repair requires in vivo (i.o. animal models) evaluations prior to clinical trials. In order to examine the efficacy of a novel graft, a chronic TMP animal model mimicking clinical condition of chronic TMPs Is required. The aim of this study was to develop techniques for creating a chronic TMP model in rats.

AB - Tympanic membrane perforation (TMP) is a common pathology. Most TMPs heal spontaneously within 10 days. Those that fail to heal within three months are defined as chronic TMPs which surgical grafting is an option tor treatment, typically with autografts. The development of new graft materials for tympanic membrane repair requires in vivo (i.o. animal models) evaluations prior to clinical trials. In order to examine the efficacy of a novel graft, a chronic TMP animal model mimicking clinical condition of chronic TMPs Is required. The aim of this study was to develop techniques for creating a chronic TMP model in rats.

KW - Tympanic membrane perforation

KW - Chronic

KW - Animal model

KW - Rat

KW - Ventilation tube

KW - Histology

U2 - 10.4225/23/5a29e8242810c

DO - 10.4225/23/5a29e8242810c

M3 - Doctoral Thesis

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Creating Chronic Tympanic Membrane Perforations in a Rat Model

Abstract

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