Creating Chronic Tympanic Membrane Perforations in a Rat Model

Yu-Yu Wang

    Research output: ThesisDoctoral Thesis

    80 Downloads (Pure)

    Abstract

    Tympanic membrane perforation (TMP) is a common pathology. Most TMPs heal spontaneously within 10 days. Those that fail to heal within three months are defined as chronic TMPs which surgical grafting is an option tor treatment, typically with autografts. The development of new graft materials for tympanic membrane repair requires in vivo (i.o. animal models) evaluations prior to clinical trials. In order to examine the efficacy of a novel graft, a chronic TMP animal model mimicking clinical condition of chronic TMPs Is required. The aim of this study was to develop techniques for creating a chronic TMP model in rats.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Thesis sponsors
    Award date8 Nov 2017
    DOIs
    Publication statusUnpublished - 2017

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    Tympanic Membrane Perforation
    Thymidine Monophosphate
    Animal Models
    Transplants
    Tympanic Membrane
    Autografts
    Clinical Trials
    Pathology

    Cite this

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    title = "Creating Chronic Tympanic Membrane Perforations in a Rat Model",
    abstract = "Tympanic membrane perforation (TMP) is a common pathology. Most TMPs heal spontaneously within 10 days. Those that fail to heal within three months are defined as chronic TMPs which surgical grafting is an option tor treatment, typically with autografts. The development of new graft materials for tympanic membrane repair requires in vivo (i.o. animal models) evaluations prior to clinical trials. In order to examine the efficacy of a novel graft, a chronic TMP animal model mimicking clinical condition of chronic TMPs Is required. The aim of this study was to develop techniques for creating a chronic TMP model in rats.",
    keywords = "Tympanic membrane perforation, Chronic, Animal model, Rat, Ventilation tube, Histology",
    author = "Yu-Yu Wang",
    year = "2017",
    doi = "10.4225/23/5a29e8242810c",
    language = "English",
    school = "The University of Western Australia",

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    Wang, Y-Y 2017, 'Creating Chronic Tympanic Membrane Perforations in a Rat Model', Doctor of Philosophy, The University of Western Australia. https://doi.org/10.4225/23/5a29e8242810c

    Creating Chronic Tympanic Membrane Perforations in a Rat Model. / Wang, Yu-Yu.

    2017.

    Research output: ThesisDoctoral Thesis

    TY - THES

    T1 - Creating Chronic Tympanic Membrane Perforations in a Rat Model

    AU - Wang, Yu-Yu

    PY - 2017

    Y1 - 2017

    N2 - Tympanic membrane perforation (TMP) is a common pathology. Most TMPs heal spontaneously within 10 days. Those that fail to heal within three months are defined as chronic TMPs which surgical grafting is an option tor treatment, typically with autografts. The development of new graft materials for tympanic membrane repair requires in vivo (i.o. animal models) evaluations prior to clinical trials. In order to examine the efficacy of a novel graft, a chronic TMP animal model mimicking clinical condition of chronic TMPs Is required. The aim of this study was to develop techniques for creating a chronic TMP model in rats.

    AB - Tympanic membrane perforation (TMP) is a common pathology. Most TMPs heal spontaneously within 10 days. Those that fail to heal within three months are defined as chronic TMPs which surgical grafting is an option tor treatment, typically with autografts. The development of new graft materials for tympanic membrane repair requires in vivo (i.o. animal models) evaluations prior to clinical trials. In order to examine the efficacy of a novel graft, a chronic TMP animal model mimicking clinical condition of chronic TMPs Is required. The aim of this study was to develop techniques for creating a chronic TMP model in rats.

    KW - Tympanic membrane perforation

    KW - Chronic

    KW - Animal model

    KW - Rat

    KW - Ventilation tube

    KW - Histology

    U2 - 10.4225/23/5a29e8242810c

    DO - 10.4225/23/5a29e8242810c

    M3 - Doctoral Thesis

    ER -