Creatine Supplementation to Attenuate Inflammation and Oxidative Stress in Fetal Lung and Pediatric Airway Inflammation

Jane Choi

doi:10.26182/5fp2-bn88

Creatine Supplementation to Attenuate Inflammation and Oxidative Stress in Fetal Lung and Pediatric Airway Inflammation

Jane Choi

Research output: Thesis › Doctoral Thesis

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Abstract

Intrauterine infection or inflammation is a common antecedent of preterm birth that adversely affects fetal lung development. Creatine is a safe nutritional supplement with anti-inflammatory and antioxidant benefits that presents a novel approach to mitigate the adverse effects of intrauterine inflammation on fetal lung development. This thesis investigated whether creatine supplementation attenuates pulmonary inflammation and oxidative stress in fetal lung and pediatric airway inflammation. The results support the therapeutic potential of creatine as a perinatal anti-inflammatory and antioxidant adjuvant and highlight future research directions to elucidate the underlying mechanisms driving the pulmonary responses to creatine supplementation.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Pillow, Jane, Supervisor Choi, Yu Suk, Supervisor Terrill, Jessica, Supervisor Kicic, Anthony, Supervisor Currie, Andrew, Supervisor, External person
Thesis sponsors	Australian Government Research Training Program
Award date	30 Oct 2023
DOIs	https://doi.org/10.26182/5fp2-bn88
Publication status	Unpublished - 2023

Embargo information

Embargoed from 30/10/2023 to 31/12/2024. Made publicly available on 31/12/2024

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10.26182/5fp2-bn88

THESIS - DOCTOR OF PHILOSOPHY - CHOI Younghyun Jane - 2023
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Cite this

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KW - Fetal Lung Development

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Creatine Supplementation to Attenuate Inflammation and Oxidative Stress in Fetal Lung and Pediatric Airway Inflammation

Abstract

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