Creatine Supplementation to Attenuate Inflammation and Oxidative Stress in Fetal Lung and Pediatric Airway Inflammation

Research output: ThesisDoctoral Thesis

Abstract

Intrauterine infection or inflammation is a common antecedent of preterm birth that adversely affects fetal lung development. Creatine is a safe nutritional supplement with anti-inflammatory and antioxidant benefits that presents a novel approach to mitigate the adverse effects of intrauterine inflammation on fetal lung development. This thesis investigated whether creatine supplementation attenuates pulmonary inflammation and oxidative stress in fetal lung and pediatric airway inflammation. The results support the therapeutic potential of creatine as a perinatal anti-inflammatory and antioxidant adjuvant and highlight future research directions to elucidate the underlying mechanisms driving the pulmonary responses to creatine supplementation.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Pillow, Jane, Supervisor
  • Choi, Yu Suk, Supervisor
  • Terrill, Jessica, Supervisor
  • Kicic, Anthony, Supervisor
  • Currie, Andrew, Supervisor, External person
Thesis sponsors
Award date30 Oct 2023
DOIs
Publication statusUnpublished - 2023

Embargo information

  • Embargoed from 30/10/2023 to 31/12/2024. Will become publicly avaliable on 31/12/2024

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