TY - JOUR
T1 - Creatine supplementation does not add to resistance training effects in prostate cancer patients under androgen deprivation therapy
T2 - A double-blind randomized trial
AU - Fairman, Ciaran M.
AU - Kendall, Kristina L.
AU - Newton, Robert U.
AU - Hart, Nicolas H.
AU - Taaffe, Dennis R.
AU - Lopez, Pedro
AU - Chee, Raphael
AU - Tang, Colin I.
AU - Galvão, Daniel A.
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2025/2
Y1 - 2025/2
N2 - Objectives: Androgen deprivation therapy (ADT) leads to loss of lean mass (LM) and reduced strength and physical function. Resistance exercise alone can counteract these changes; however, it is unknown if the addition of creatine supplementation can further protect against these ADT-induced toxicities. We compared the effects of creatine supplementation with resistance exercise versus resistance exercise alone in patients with prostate cancer undergoing ADT on LM, muscle strength, and physical function. Design: A 12-week randomized trial. Methods: Men with prostate cancer receiving ADT (n = 30) were randomized to either resistance exercise + placebo (PLA) or resistance exercise + creatine (SUPP), with both groups undertaking supervised exercise 3 days per week. Outcomes included whole body and appendicular LM and fat mass (FM) assessed by dual-energy X-ray absorptiometry, as well as muscle strength (chest press, seated low, leg press), and physical function (timed up-and-go, chair rise, 400-m walk) assessed at baseline and following the intervention. Results: Patients were aged 59–84 years with a BMI of 28.6 kg·m−2. PLA completed a mean of 30 sessions (83 %) and SUPP a mean of 33 sessions (92 %). Despite similar within-group improvements (p < 0.05) in whole-body LM (PLA + 0.6 kg, SUPP + 1.3 kg), appendicular LM (PLA + 0.5 kg, SUPP + 0.6 kg), muscle strength (PLA + 8.8–49.3 kg, SUPP + 9.4–40.4 kg) and physical function, there were no between group differences (p = 0.078–0.951). No adverse events were reported due to creatine supplementation or resistance exercise. Conclusions: A short-term program of resistance exercise alone results in meaningful improvements in LM, muscle strength and physical function, with no additional effects of creatine supplementation.
AB - Objectives: Androgen deprivation therapy (ADT) leads to loss of lean mass (LM) and reduced strength and physical function. Resistance exercise alone can counteract these changes; however, it is unknown if the addition of creatine supplementation can further protect against these ADT-induced toxicities. We compared the effects of creatine supplementation with resistance exercise versus resistance exercise alone in patients with prostate cancer undergoing ADT on LM, muscle strength, and physical function. Design: A 12-week randomized trial. Methods: Men with prostate cancer receiving ADT (n = 30) were randomized to either resistance exercise + placebo (PLA) or resistance exercise + creatine (SUPP), with both groups undertaking supervised exercise 3 days per week. Outcomes included whole body and appendicular LM and fat mass (FM) assessed by dual-energy X-ray absorptiometry, as well as muscle strength (chest press, seated low, leg press), and physical function (timed up-and-go, chair rise, 400-m walk) assessed at baseline and following the intervention. Results: Patients were aged 59–84 years with a BMI of 28.6 kg·m−2. PLA completed a mean of 30 sessions (83 %) and SUPP a mean of 33 sessions (92 %). Despite similar within-group improvements (p < 0.05) in whole-body LM (PLA + 0.6 kg, SUPP + 1.3 kg), appendicular LM (PLA + 0.5 kg, SUPP + 0.6 kg), muscle strength (PLA + 8.8–49.3 kg, SUPP + 9.4–40.4 kg) and physical function, there were no between group differences (p = 0.078–0.951). No adverse events were reported due to creatine supplementation or resistance exercise. Conclusions: A short-term program of resistance exercise alone results in meaningful improvements in LM, muscle strength and physical function, with no additional effects of creatine supplementation.
KW - Androgen deprivation
KW - Creatine supplementation
KW - Lean mass
KW - Resistance exercise
UR - http://www.scopus.com/inward/record.url?scp=85205482184&partnerID=8YFLogxK
U2 - 10.1016/j.jsams.2024.09.002
DO - 10.1016/j.jsams.2024.09.002
M3 - Article
C2 - 39366880
AN - SCOPUS:85205482184
SN - 1440-2440
VL - 28
SP - 118
EP - 124
JO - Journal of Science and Medicine in Sport
JF - Journal of Science and Medicine in Sport
IS - 2
ER -