Correlation of ultra-low dose chest CT findings with physiologic measures of asbestosis

David Manners, Patrick Wong, Conor Murray, Joelin Teh, Yi Jin Kwok, Nick de Klerk, Helman Alfonso, Peter Franklin, Alison Reid, A. W Bill Musk, Fraser J H Brims

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: The correlation between ultra low dose computed tomography (ULDCT)-detected parenchymal lung changes and pulmonary function abnormalities is not well described. This study aimed to determine the relationship between ULDCT-detected interstitial lung disease (ILD) and measures of pulmonary function in an asbestos-exposed population. Methods: Two thoracic radiologists independently categorised prone ULDCT scans from 143 participants for ILD appearances as absent (score 0), probable (1) or definite (2) without knowledge of asbestos exposure or lung function. Pulmonary function measures included spirometry and diffusing capacity to carbon monoxide (DLCO). Results: Participants were 92% male with a median age of 73.0 years. CT dose index volume was between 0.6 and 1.8 mGy. Probable or definite ILD was reported in 63 (44.1%) participants. Inter-observer agreement was good (k = 0.613, p < 0.001). There was a statistically significant correlation between the ILD score and both forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) (r = -0.17, p = 0.04 and r = -0.20, p = 0.02). There was a strong correlation between ILD score and DLCO (r = -0.34, p < 0.0001). Conclusion: Changes consistent with ILD on ULDCT correlate well with corresponding reductions in gas transfer, similar to standard CT. In asbestos-exposed populations, ULDCT may be adequate to detect radiological changes consistent with asbestosis. Key Points: • Interobserver agreement for the ILD score using prone ULDCT is good.• Prone ULDCT appearances of ILD correlate with changes in spirometric observations.• Prone ULDCT appearances of ILD correlate strongly with changes in gas transfer.• Prone ULDCT may provide sufficient radiological evidence to inform the diagnosis of asbestosis.

Original languageEnglish
Pages (from-to)3485-3490
Number of pages6
JournalEuropean Radiology
Volume27
Issue number8
DOIs
Publication statusPublished - Aug 2017

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Asbestosis
Interstitial Lung Diseases
Thorax
Tomography
Asbestos
Lung
Gases
Spirometry
Vital Capacity
Forced Expiratory Volume
Carbon Monoxide
Population

Cite this

Manners, David ; Wong, Patrick ; Murray, Conor ; Teh, Joelin ; Kwok, Yi Jin ; de Klerk, Nick ; Alfonso, Helman ; Franklin, Peter ; Reid, Alison ; Musk, A. W Bill ; Brims, Fraser J H. / Correlation of ultra-low dose chest CT findings with physiologic measures of asbestosis. In: European Radiology. 2017 ; Vol. 27, No. 8. pp. 3485-3490.
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abstract = "Objectives: The correlation between ultra low dose computed tomography (ULDCT)-detected parenchymal lung changes and pulmonary function abnormalities is not well described. This study aimed to determine the relationship between ULDCT-detected interstitial lung disease (ILD) and measures of pulmonary function in an asbestos-exposed population. Methods: Two thoracic radiologists independently categorised prone ULDCT scans from 143 participants for ILD appearances as absent (score 0), probable (1) or definite (2) without knowledge of asbestos exposure or lung function. Pulmonary function measures included spirometry and diffusing capacity to carbon monoxide (DLCO). Results: Participants were 92{\%} male with a median age of 73.0 years. CT dose index volume was between 0.6 and 1.8 mGy. Probable or definite ILD was reported in 63 (44.1{\%}) participants. Inter-observer agreement was good (k = 0.613, p < 0.001). There was a statistically significant correlation between the ILD score and both forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) (r = -0.17, p = 0.04 and r = -0.20, p = 0.02). There was a strong correlation between ILD score and DLCO (r = -0.34, p < 0.0001). Conclusion: Changes consistent with ILD on ULDCT correlate well with corresponding reductions in gas transfer, similar to standard CT. In asbestos-exposed populations, ULDCT may be adequate to detect radiological changes consistent with asbestosis. Key Points: • Interobserver agreement for the ILD score using prone ULDCT is good.• Prone ULDCT appearances of ILD correlate with changes in spirometric observations.• Prone ULDCT appearances of ILD correlate strongly with changes in gas transfer.• Prone ULDCT may provide sufficient radiological evidence to inform the diagnosis of asbestosis.",
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Correlation of ultra-low dose chest CT findings with physiologic measures of asbestosis. / Manners, David; Wong, Patrick; Murray, Conor; Teh, Joelin; Kwok, Yi Jin; de Klerk, Nick; Alfonso, Helman; Franklin, Peter; Reid, Alison; Musk, A. W Bill; Brims, Fraser J H.

In: European Radiology, Vol. 27, No. 8, 08.2017, p. 3485-3490.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation of ultra-low dose chest CT findings with physiologic measures of asbestosis

AU - Manners, David

AU - Wong, Patrick

AU - Murray, Conor

AU - Teh, Joelin

AU - Kwok, Yi Jin

AU - de Klerk, Nick

AU - Alfonso, Helman

AU - Franklin, Peter

AU - Reid, Alison

AU - Musk, A. W Bill

AU - Brims, Fraser J H

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N2 - Objectives: The correlation between ultra low dose computed tomography (ULDCT)-detected parenchymal lung changes and pulmonary function abnormalities is not well described. This study aimed to determine the relationship between ULDCT-detected interstitial lung disease (ILD) and measures of pulmonary function in an asbestos-exposed population. Methods: Two thoracic radiologists independently categorised prone ULDCT scans from 143 participants for ILD appearances as absent (score 0), probable (1) or definite (2) without knowledge of asbestos exposure or lung function. Pulmonary function measures included spirometry and diffusing capacity to carbon monoxide (DLCO). Results: Participants were 92% male with a median age of 73.0 years. CT dose index volume was between 0.6 and 1.8 mGy. Probable or definite ILD was reported in 63 (44.1%) participants. Inter-observer agreement was good (k = 0.613, p < 0.001). There was a statistically significant correlation between the ILD score and both forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) (r = -0.17, p = 0.04 and r = -0.20, p = 0.02). There was a strong correlation between ILD score and DLCO (r = -0.34, p < 0.0001). Conclusion: Changes consistent with ILD on ULDCT correlate well with corresponding reductions in gas transfer, similar to standard CT. In asbestos-exposed populations, ULDCT may be adequate to detect radiological changes consistent with asbestosis. Key Points: • Interobserver agreement for the ILD score using prone ULDCT is good.• Prone ULDCT appearances of ILD correlate with changes in spirometric observations.• Prone ULDCT appearances of ILD correlate strongly with changes in gas transfer.• Prone ULDCT may provide sufficient radiological evidence to inform the diagnosis of asbestosis.

AB - Objectives: The correlation between ultra low dose computed tomography (ULDCT)-detected parenchymal lung changes and pulmonary function abnormalities is not well described. This study aimed to determine the relationship between ULDCT-detected interstitial lung disease (ILD) and measures of pulmonary function in an asbestos-exposed population. Methods: Two thoracic radiologists independently categorised prone ULDCT scans from 143 participants for ILD appearances as absent (score 0), probable (1) or definite (2) without knowledge of asbestos exposure or lung function. Pulmonary function measures included spirometry and diffusing capacity to carbon monoxide (DLCO). Results: Participants were 92% male with a median age of 73.0 years. CT dose index volume was between 0.6 and 1.8 mGy. Probable or definite ILD was reported in 63 (44.1%) participants. Inter-observer agreement was good (k = 0.613, p < 0.001). There was a statistically significant correlation between the ILD score and both forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) (r = -0.17, p = 0.04 and r = -0.20, p = 0.02). There was a strong correlation between ILD score and DLCO (r = -0.34, p < 0.0001). Conclusion: Changes consistent with ILD on ULDCT correlate well with corresponding reductions in gas transfer, similar to standard CT. In asbestos-exposed populations, ULDCT may be adequate to detect radiological changes consistent with asbestosis. Key Points: • Interobserver agreement for the ILD score using prone ULDCT is good.• Prone ULDCT appearances of ILD correlate with changes in spirometric observations.• Prone ULDCT appearances of ILD correlate strongly with changes in gas transfer.• Prone ULDCT may provide sufficient radiological evidence to inform the diagnosis of asbestosis.

KW - Asbestos

KW - Asbestosis

KW - Multidetector computed tomography

KW - Respiratory function tests

KW - Screening

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