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Abstract
Spaceflight associated neuro-ocular syndrome (SANS) is common amongst astronauts on long duration space missions and is associated with signs consistent with elevated cerebrospinal fluid (CSF) pressure. Additionally, CSF pressure has been found to be elevated in a significant proportion of astronauts in whom lumbar puncture was performed after successful mission completion. We have developed a retinal photoplethysmographic technique to measure retinal vein pulsation amplitudes. This technique has enabled the development of a non-invasive CSF pressure measurement apparatus. We tested the system on healthy volunteers in the sitting and supine posture to mimic the range of tilt table extremes and estimated the induced CSF pressure change using measurements from the CSF hydrostatic indifferent point. We found a significant relationship between pulsation amplitude change and estimated CSF pressure change (p < 0.0001) across a range from 2.7 to 7.1 mmHg. The increase in pulse amplitude was highest in the sitting posture with greater estimated CSF pressure increase (p < 0.0001), in keeping with physiologically predicted CSF pressure response. This technique may be useful for non-invasive measurement of CSF pressure fluctuations during long-term space voyages.
Original language | English |
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Article number | 28 |
Journal | npj Microgravity |
Volume | 9 |
Issue number | 1 |
DOIs | |
Publication status | Published - Dec 2023 |
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Dive into the research topics of 'Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change'. Together they form a unique fingerprint.Projects
- 1 Finished
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Orbital Pressure Alteration and Interactions with Intracranial and Intraocular Pressure
Morgan, W. (Investigator 01) & Cringle, S. (Investigator 02)
NHMRC National Health and Medical Research Council
1/01/19 → 31/12/23
Project: Research